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unfolded protein [endoplasmic reticulum quality control compartment]
Stable Identifier
R-HSA-912296
Type
Genes and Transcripts [GenomeEncodedEntity]
Species
Homo sapiens
Compartment
endoplasmic reticulum quality control compartment
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with N-glycosylation of proteins (Homo sapiens)
Defective MAN1B1 causes MRT15 (Homo sapiens)
Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch) (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch) (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch) (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8a [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
Calnexin/calreticulin cycle (Homo sapiens)
ER Quality Control Compartment (ERQC) (Homo sapiens)
EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5 (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
MAN1B1 hydrolyses 1,2-linked mannose (a branch) (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8a [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
MAN1B1 hydrolyses 1,2-linked mannose (c branch) (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8c [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
MAN1B1 hydrolyses a second 1,2-linked mannose (a branch) (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)7aa [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8a [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 (Homo sapiens)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8a [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8c [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8a [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8c [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Homo sapiens)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8a [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8c [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
Incorrectly folded glycoproteins translocate to the ERQC (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi (Homo sapiens)
Glycoproteins with Man8 N-glycans [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8a [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8c [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein [endoplasmic reticulum quality control compartment] (Homo sapiens)
Participates
as a component of
unfolded protein:(GlcNAc)2 (Man)7aa [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8c [endoplasmic reticulum quality control compartment] (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)5 [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] (Homo sapiens)
unfolded protein:(GlcNAc)2 (Man)8a [endoplasmic reticulum quality control compartment] (Homo sapiens)
Cross References
ChEBI
36080
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