Phosphorylation of STAT2

Stable Identifier
R-HSA-909732
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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STAT2 recruited to the IFNAR1 subunit then becomes tyrosine phosphorylated on residue 690 by TYK2 kinase. This phosphotyrosine provides a docking site for recruitment of STAT1 to IFNAR1, which is then tyrosine phosphorylated and activated.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created