Reactome | Phosphorylation of STAT2

Phosphorylation of STAT2

Stable Identifier

R-HSA-909732

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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STAT2 recruited to the IFNAR1 subunit then becomes tyrosine phosphorylated on residue 690 by TYK2 kinase. This phosphotyrosine provides a docking site for recruitment of STAT1 to IFNAR1, which is then tyrosine phosphorylated and activated.

Literature References

PubMed ID	Title	Journal	Year
16987978	The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells Geiger, TR, Martin, JM	J Virol	2006
10542297	Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase Fish, EN, Leaman, DW, Rani, MR, Ransohoff, RM, Croze, E, Wolfman, A, Leung, S, Han, Y	J Biol Chem	1999
8197134	Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein Horvath, CM, Stark, GR, Darnell JE, Jr, Kerr, IM, Improta, T, Schindler, C	Proc Natl Acad Sci U S A	1994