Phosphorylation of INFAR1 by TYK2

Stable Identifier
R-HSA-909730
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TYK2 functions as part of a receptor complex to trigger intracellular signaling in response to IFNA/B. TYK2 bound to IFNAR1 subunit is activated in response to IFNA/B treatment and this in turn phosphorylates two tyrosine residues Y466 and Y481 in the juxta-membrane region of IFNAR1.

Literature References
PubMed ID Title Journal Year
8605876 Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein

Yan, H, Krishnan, K, Greenlund, AC, Gupta, S, Lim, JT, Schreiber, RD, Schindler, CW, Krolewski, JJ

EMBO J 1996
7526154 Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase

Colamonici, O, Yan, H, Domanski, P, Handa, R, Smalley, D, Mullersman, J, Witte, M, Krishnan, K, Krolewski, J

Mol Cell Biol 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created