TYK2 functions as part of a receptor complex to trigger intracellular signaling in response to IFNA/B. TYK2 bound to IFNAR1 subunit is activated in response to IFNA/B treatment and this in turn phosphorylates two tyrosine residues Y466 and Y481 in the juxta-membrane region of IFNAR1.
Krolewski, J, Yan, H, Colamonici, O, Handa, R, Witte, M, Smalley, D, Mullersman, J, Domanski, P, Krishnan, K
Gupta, S, Greenlund, AC, Krolewski, JJ, Yan, H, Schreiber, RD, Schindler, CW, Lim, JT, Krishnan, K
protein tyrosine kinase activity of IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane]
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