TYK2 functions as part of a receptor complex to trigger intracellular signaling in response to IFNA/B. TYK2 bound to IFNAR1 subunit is activated in response to IFNA/B treatment and this in turn phosphorylates two tyrosine residues Y466 and Y481 in the juxta-membrane region of IFNAR1.
Yan, H, Krishnan, K, Greenlund, AC, Gupta, S, Lim, JT, Schreiber, RD, Schindler, CW, Krolewski, JJ
Colamonici, O, Yan, H, Domanski, P, Handa, R, Smalley, D, Mullersman, J, Witte, M, Krishnan, K, Krolewski, J
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