Reactome | Interaction of IRF9 with p-STAT2:p-STAT1

Interaction of IRF9 with p-STAT2:p-STAT1

Stable Identifier

R-HSA-909725

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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Interaction of IRF9 with p-STAT2:p-STAT1

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The phosphorylated STAT2:STAT1 heterodimer associates with interferon-regulating factor 9 (IRF9) to form the interferon-stimulated gene factor 3 (ISGF3) complex.

Literature References

PubMed ID	Title	Journal	Year
9242679	Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 Martinez-Moczygemba, M, Gutch, MJ, French, DL, Reich, NC	J Biol Chem	1997
8621447	Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha Li, X, Leung, S, Qureshi, S, Darnell JE, Jr, Stark, GR	J Biol Chem	1996
7537377	Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3 Qureshi, SA, Salditt-Georgieff, M, Darnell JE, Jr	Proc Natl Acad Sci U S A	1995