Reactome | Interaction of IRF9 with p-STAT2:p-STAT1

Interaction of IRF9 with p-STAT2:p-STAT1

Stable Identifier

R-HSA-909725

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Interaction of IRF9 with p-STAT2:p-STAT1

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The phosphorylated STAT2:STAT1 heterodimer associates with interferon-regulating factor 9 (IRF9) to form the interferon-stimulated gene factor 3 (ISGF3) complex.

Literature References

PubMed ID	Title	Journal	Year
8621447	Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha Stark, GR, Darnell JE, Jr, Qureshi, S, Li, X, Leung, S	J Biol Chem	1996
9242679	Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 French, DL, Martinez-Moczygemba, M, Reich, NC, Gutch, MJ	J Biol Chem	1997
7537377	Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3 Salditt-Georgieff, M, Darnell JE, Jr, Qureshi, SA	Proc Natl Acad Sci U S A	1995