Reactome | p-S727,Y701-STAT1-1 [cytosol]

p-S727,Y701-STAT1-1

Stable Identifier

R-HSA-909563

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-STAT1(Y701, S727), p-STAT1-alpha, Phospho-STAT1, p-S727,Y701-STAT1 isoform 1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P42224-1 STAT1

Gene Names

STAT1

Other Identifiers

0003290692

0004120546

0007000128

11726689_a_at

11726690_a_at

11743353_s_at

16906534

1BF5

1YVL

200887_s_at

209969_s_at

2KA6

32859_at

32860_g_at

33338_at

33339_g_at

3WWT

4049

6772

8057744

931

982

A_23_P56630

A_24_P274270

AFFX-HUMISGF3A/M97935_3_at

AFFX-HUMISGF3A/M97935_5_at

AFFX-HUMISGF3A/M97935_MA_at

AFFX-HUMISGF3A/M97935_MB_at

CAB004049

CCDS2309

CCDS42793

D2KFR9

ENSG00000115415

ENSP00000354394

ENSP00000376136

ENSP00000386244

ENST00000361099

ENST00000392322

ENST00000409465

EntrezGene:6772

g12803734_3p_a_at

g6274551_3p_s_at

GE58182

GO:0000122

GO:0000790

GO:0000978

GO:0000979

GO:0000983

GO:0001047

GO:0001937

GO:0002053

GO:0003340

GO:0003677

GO:0003690

GO:0003700

GO:0004871

GO:0005164

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006915

GO:0007165

GO:0007259

GO:0008015

GO:0010742

GO:0016032

GO:0016525

GO:0019899

GO:0030424

GO:0030425

GO:0033209

GO:0034097

GO:0035257

GO:0035456

GO:0035458

GO:0035722

GO:0042802

GO:0042803

GO:0042981

GO:0043124

GO:0043434

GO:0045296

GO:0045648

GO:0045893

GO:0045944

GO:0046725

GO:0048471

GO:0048661

GO:0051591

GO:0051607

GO:0060333

GO:0060334

GO:0060337

GO:0060338

GO:0061326

GO:0070491

GO:0071346

GO:0072136

GO:0072162

GO:0072308

HGNC:11362

HPA000931

HPA000982

Hs.743244

ILMN_1690105

ILMN_1691364

ILMN_1777325

LRG_111

LRG_111t1

M97935_s_at

M97936_at

MIM:600555

MIM:613796

MIM:614162

MIM:614892

NM_007315

NM_139266

NP_009330

NP_644671

PF00017

PF01017

PF02864

PF02865

PF12162

PH_hs_0001863

SM00964

STAT1

STAT1-201

STAT1-202

STAT1-204

TC02002624.hg

uc002usj.3

uc002usk.3

uc010fse.3

UPI0000000C47

UPI00000473FB

XM_006712718

XM_017004783

XP_006712781

XP_016860272

XR_001738914

XR_001738915

Participant Of

hasMember

Tyrosine/serine phosphorylated STAT1, STAT3 [cytosol]

hasComponent

IFNG-activated factor (GAF) [cytosol]

Other forms of this molecule

STAT1-1 [nucleoplasm]

p-S727,Y701-STAT1-1 [nucleoplasm]

STAT1-1 [cytosol]

p-Y701-STAT1-1 [nucleoplasm]

p-Y701-STAT1-1 [cytosol]

Inferred To

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Bos taurus)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Canis familiaris)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Gallus gallus)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Mus musculus)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Rattus norvegicus)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Sus scrofa)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Xenopus tropicalis)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Bos taurus)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Caenorhabditis elegans)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Canis familiaris)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Danio rerio)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Gallus gallus)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Mus musculus)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Rattus norvegicus)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Sus scrofa)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Taeniopygia guttata)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 727

Coordinate

727

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 701

Coordinate

701

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_009330.1, XP_006712781.1, NP_644671.1

ZINC - Metabolites

STAT1_HUMAN

GeneCards

P42224

ZINC - Substances

STAT1_HUMAN

DOCK Blaster

1BF5, 1YVL, 3WWT

ZINC - Biogenic

STAT1_HUMAN

ZINC target

P42224

PRO

P42224

ZINC - Predictions - Purchasable

STAT1_HUMAN

Orphanet

15563

PDB

2KA6, 1BF5, 3WWT, 1YVL

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	STAT2 [cytosol] (R-HSA-882029) p-Y-STAT2 [cytosol] (R-HSA-8987235) p-Y690-STAT2 [cytosol] (R-HSA-909683) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673)	0.818	14
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.706	6
UniProt:P15260 IFNGR1	2	p-Y440-IFNGR1 [plasma membrane] (R-HSA-873798) IFNGR1 [plasma membrane] (R-HSA-629623)	0.69	4
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048)	0.669	3
IntAct:EBI-9984951 IRF1			0.669	3
UniProt:Q8N9N8 EIF1A			0.666	4
UniProt:P42224 STAT1	5	p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.643	4
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079)	0.609	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.589	6
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.576	3
UniProt:Q01804 OTUD4			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:P07239 DUSP			0.552	3
UniProt:P03255-2			0.544	2
UniProt:P10276 RARA	2	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) RARA [nucleoplasm] (R-HSA-446164)	0.532	4
UniProt:Q77M19 Q77M19			0.527	4
UniProt:Q00978 IRF9	2	IRF9 [cytosol] (R-HSA-879183) IRF9 [nucleoplasm] (R-HSA-913522)	0.527	3
UniProt:P26664 POLG			0.524	5
IntAct:EBI-10097350 STAT			0.524	2
UniProt:Q4VW77 Q4VW77			0.524	2
UniProt:Q01094 E2F1	2	p-E2F1 [nucleoplasm] (R-HSA-187911) E2F1 [nucleoplasm] (R-HSA-68639)	0.524	2
UniProt:P03255-1			0.508	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.508	2
UniProt:P19793 RXRA	2	RXRA [nucleoplasm] (R-HSA-381319) p-S21-RXRA [nucleoplasm] (R-HSA-5334811)	0.508	2
UniProt:P17181 IFNAR1	2	p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675) IFNAR1 [plasma membrane] (R-HSA-877334)	0.499	2
UniProt:P48551 IFNAR2			0.499	2
IntAct:EBI-9825772 C-FOS PROMOTER REGION			0.499	3
IntAct:EBI-10097414 FOXP3			0.499	2
UniProt:P11277 SPTB	1	SPTB [cytosol] (R-HSA-391565)	0.488	2
UniProt:P27958-PRO_0000037576			0.463	4
UniProt:Q9UIV1 CNOT7	1	CNOT7 [cytosol] (R-HSA-429877)	0.463	2