Reactome | p-S727,Y701-STAT1-1 [cytosol]

p-S727,Y701-STAT1-1 [cytosol]

Stable Identifier

R-HSA-909563

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-STAT1(Y701, S727), p-STAT1-alpha, Phospho-STAT1, p-S727,Y701-STAT1 isoform 1

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External Reference Information

External Reference

UniProt:P42224-1 STAT1

Gene Names

STAT1

Other Identifiers

0003290692

0004120546

0007000128

11726689_a_at

11726690_a_at

11743353_s_at

16906534

1BF5

1YVL

200887_s_at

209969_s_at

2592274

2592275

2592276

2592279

2592283

2592284

2592286

2592289

2592292

2592294

2592296

2592298

2592299

2592300

2592303

2592304

2592306

2592309

2592310

2592317

2592318

2592319

2592320

2592321

2592324

2592325

2592326

2592329

2592330

2592331

2592332

2KA6

32859_at

32860_g_at

33338_at

33339_g_at

3WWT

4049

6772

8057744

931

982

A_23_P56630

A_24_P274270

AAB64012

AAH02704

AAP35905

AAW56072

AAY24183

AC067945

ADA59516

AFFX-HUMISGF3A/M97935_3_at

AFFX-HUMISGF3A/M97935_5_at

AFFX-HUMISGF3A/M97935_MA_at

AFFX-HUMISGF3A/M97935_MB_at

AK292604

AK315002

AY865620

BAF85293

BAG37497

BC002704

BT007241

CAB004049

CAH18430

CCDS2309

CCDS42793

CH471058

CR749636

D2KFR9

E7ENM1

E7EPD2

E9PH66

EAX10850

EAX10851

EAX10852

EAX10855

ENSG00000115415

ENSP00000354394

ENSP00000376136

ENSP00000386244

ENST00000361099

ENST00000392322

ENST00000409465

EntrezGene:6772

g12803734_3p_a_at

g6274551_3p_s_at

GE58182

GO:0000122

GO:0000228

GO:0000790

GO:0000978

GO:0000979

GO:0000981

GO:0000982

GO:0000983

GO:0001937

GO:0002053

GO:0002230

GO:0002376

GO:0003013

GO:0003340

GO:0003674

GO:0003677

GO:0003690

GO:0003700

GO:0005164

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006355

GO:0006950

GO:0007165

GO:0007221

GO:0007259

GO:0007584

GO:0008015

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009058

GO:0009612

GO:0010742

GO:0014070

GO:0016032

GO:0016525

GO:0019221

GO:0019899

GO:0030154

GO:0030424

GO:0030425

GO:0031730

GO:0032727

GO:0032869

GO:0032991

GO:0033209

GO:0034097

GO:0034641

GO:0035035

GO:0035257

GO:0035456

GO:0035458

GO:0038113

GO:0038114

GO:0042393

GO:0042493

GO:0042542

GO:0042592

GO:0042802

GO:0042803

GO:0042981

GO:0043124

GO:0043226

GO:0043434

GO:0043565

GO:0044389

GO:0044403

GO:0045296

GO:0045648

GO:0045893

GO:0045944

GO:0046725

GO:0048471

GO:0048646

GO:0048661

GO:0048856

GO:0051591

GO:0051607

GO:0051721

GO:0051770

GO:0060333

GO:0060334

GO:0060337

GO:0061326

GO:0070102

GO:0070106

GO:0070491

GO:0070757

GO:0071345

GO:0071346

GO:0071407

GO:0072136

GO:0072162

GO:0072308

GO:1990841

GU211347

HGNC:11362

HPA000931

HPA000982

ILMN_1690105

ILMN_1691364

ILMN_1777325

IPR000980

IPR001217

IPR008967

IPR012345

IPR013799

IPR013800

IPR013801

IPR015988

IPR022752

IPR035859

IPR036535

IPR036860

IPR038295

J3KPM9

LRG_111

M97935

M97935_s_at

M97936

M97936_at

MIM:600555

MIM:613796

MIM:614162

MIM:614892

NM_139266

NP_009330

NP_644671

PF00017

PF01017

PF02864

PF02865

PF12162

PH_hs_0001863

SM00964

STAT1

STAT1-201

STAT1-202

STAT1-204

TC02002624.hg

U18662

U18663

U18664

U18665

U18666

U18667

U18668

U18669

U18670

uc002usj.3

uc002usk.3

uc010fse.3

UPI0000000C47

UPI00000473FB

XM_017004783

XP_006712781

XP_016860272

Participant Of

hasMember

Tyrosine/serine phosphorylated STAT1, STAT3 [cytosol]

hasComponent

IFNG-activated factor (GAF) [cytosol]

Other forms of this molecule

STAT1-1 [nucleoplasm]

p-S727,Y701-STAT1-1 [nucleoplasm]

STAT1-1 [cytosol]

p-Y701-STAT1-1 [nucleoplasm]

p-Y701-STAT1-1 [cytosol]

Inferred To

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Bos taurus)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Canis familiaris)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Danio rerio)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Gallus gallus)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Mus musculus)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Rattus norvegicus)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Sus scrofa)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Xenopus tropicalis)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Bos taurus)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Caenorhabditis elegans)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Canis familiaris)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Danio rerio)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Drosophila melanogaster)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Gallus gallus)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Mus musculus)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Rattus norvegicus)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Sus scrofa)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Taeniopygia guttata)

phospho-p-S727,Y701-STAT1-1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 701

Coordinate

701

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-serine at 727

Coordinate

727

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_644671.1, NP_009330.1, XP_006712781.1

ZINC - Metabolites

STAT1_HUMAN

OpenTargets

ENSG00000115415

GeneCards

P42224

ZINC - Substances

STAT1_HUMAN

ZINC target

P42224

ZINC - Biogenic

STAT1_HUMAN

PRO

P42224

BRENDA (Homo sapiens)

2.4.2.3

ZINC - Predictions - Purchasable

STAT1_HUMAN

Orphanet

15563

PDB

1BF5, 2KA6, 1YVL, 3WWT

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	STAT2 [cytosol] (R-HSA-882029) p-Y-STAT2 [cytosol] (R-HSA-8987235) p-Y690-STAT2 [cytosol] (R-HSA-909683) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673)	0.859	15
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048)	0.744	4
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.706	6
UniProt:P15260 IFNGR1	2	p-Y440-IFNGR1 [plasma membrane] (R-HSA-873798) IFNGR1 [plasma membrane] (R-HSA-629623)	0.69	4
IntAct:EBI-9984951 IRF1			0.669	3
UniProt:Q8N9N8 EIF1A			0.666	4
UniProt:P42224 STAT1	7	p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.643	4
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.609	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.589	6
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.576	3
UniProt:Q01804 OTUD4			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:Q13813 SPTAN1	6	SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [specific granule lumen] (R-HSA-6799533) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [tertiary granule lumen] (R-HSA-6800874)	0.547	2
UniProt:P03255-2			0.544	2
UniProt:P07239 DUSP			0.544	2
UniProt:P10276 RARA	3	SUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) RARA [nucleoplasm] (R-HSA-446164)	0.532	4
UniProt:Q77M19 Q77M19			0.527	4
UniProt:Q00978 IRF9	2	IRF9 [cytosol] (R-HSA-879183) IRF9 [nucleoplasm] (R-HSA-913522)	0.527	3
UniProt:P26664 POLG			0.524	5
IntAct:EBI-10097350 STAT			0.524	2
UniProt:Q4VW77 Q4VW77			0.524	2
UniProt:Q01094 E2F1	2	p-E2F1 [nucleoplasm] (R-HSA-187911) E2F1 [nucleoplasm] (R-HSA-68639)	0.524	2
UniProt:P03255-1			0.508	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.508	2
UniProt:P19793 RXRA	3	SUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [nucleoplasm] (R-HSA-381319)	0.508	2
UniProt:P17181 IFNAR1	2	p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675) IFNAR1 [plasma membrane] (R-HSA-877334)	0.499	2
UniProt:P48551 IFNAR2			0.499	2
IntAct:EBI-9825772 C-FOS PROMOTER REGION			0.499	3
IntAct:EBI-10097414 FOXP3			0.499	2
UniProt:P11277 SPTB	1	SPTB [cytosol] (R-HSA-391565)	0.488	2
UniProt:P27958-PRO_0000037576			0.463	4
UniProt:Q9UIV1 CNOT7	1	CNOT7 [cytosol] (R-HSA-429877)	0.463	2