Reactome | p-S727,Y701-STAT1-1 [cytosol]

p-S727,Y701-STAT1-1 [cytosol]

Stable Identifier

R-HSA-909563

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-STAT1(Y701, S727), p-STAT1-alpha, Phospho-STAT1, p-S727,Y701-STAT1 isoform 1

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External Reference Information

External Reference

UniProt:P42224-1 STAT1

Gene Names

STAT1

Other Identifiers

0003290692

0007000128

11726689_a_at

11726690_a_at

11743353_s_at

16906534

200887_s_at

209969_s_at

2592269

2592273

2592274

2592275

2592276

2592279

2592281

2592282

2592283

2592284

2592286

2592289

2592292

2592294

2592296

2592298

2592299

2592300

2592303

2592304

2592306

2592309

2592310

2592317

2592318

2592319

2592320

2592321

2592324

2592325

2592326

2592329

2592330

2592331

2592332

32859_at

32860_g_at

33338_at

33339_g_at

6772

8057744

AFFX-HUMISGF3A/M97935_3_at

AFFX-HUMISGF3A/M97935_5_at

AFFX-HUMISGF3A/M97935_MA_at

AFFX-HUMISGF3A/M97935_MB_at

A_23_P56630

A_24_P274270

GE58182

GO:0000122

GO:0000785

GO:0000978

GO:0000979

GO:0000981

GO:0001937

GO:0002053

GO:0002230

GO:0002376

GO:0003013

GO:0003340

GO:0003674

GO:0003677

GO:0003690

GO:0003700

GO:0005164

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006355

GO:0006950

GO:0006952

GO:0007165

GO:0007221

GO:0007259

GO:0007584

GO:0008015

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009058

GO:0009612

GO:0010742

GO:0014070

GO:0016032

GO:0016525

GO:0019221

GO:0019899

GO:0030154

GO:0030424

GO:0030425

GO:0031730

GO:0032727

GO:0032869

GO:0032991

GO:0033209

GO:0034097

GO:0034641

GO:0035035

GO:0035257

GO:0035456

GO:0035458

GO:0038113

GO:0038114

GO:0042127

GO:0042393

GO:0042493

GO:0042542

GO:0042592

GO:0042802

GO:0042803

GO:0042981

GO:0043124

GO:0043226

GO:0043434

GO:0043565

GO:0044389

GO:0044403

GO:0045296

GO:0045648

GO:0045893

GO:0045944

GO:0046725

GO:0048471

GO:0048646

GO:0048661

GO:0048856

GO:0051591

GO:0051607

GO:0051721

GO:0051770

GO:0060333

GO:0060334

GO:0060337

GO:0061326

GO:0070102

GO:0070106

GO:0070491

GO:0070757

GO:0071345

GO:0071346

GO:0071407

GO:0072136

GO:0072162

GO:0072308

GO:1990841

HMNXSV003020843

HMNXSV003045718

ILMN_1691364

ILMN_1777325

M97935_s_at

M97936_at

PH_hs_0001863

TC02002624.hg

g12803734_3p_a_at

g6274551_3p_s_at

Participates

as a component of

IFNG-activated factor (GAF) [cytosol] (Homo sapiens)

as a member of

Tyrosine/serine phosphorylated STAT1, STAT3 [cytosol] (Homo sapiens)

Other forms of this molecule

STAT1-1 [nucleoplasm]

p-S727,Y701-STAT1-1 [nucleoplasm]

p-Y701-STAT1-1 [nucleoplasm]

p-Y701-STAT1-1 [cytosol]

STAT1-1 [cytosol]

Inferred To

phospho-dstD [cytosol] (Dictyostelium discoideum)

phospho-sta-2 [cytosol] (Caenorhabditis elegans)

phospho-sta-1 [cytosol] (Caenorhabditis elegans)

phospho-Stat1 [cytosol] (Mus musculus)

phospho-Stat1 [cytosol] (Rattus norvegicus)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Caenorhabditis elegans)

Homologues of p-S727,Y701-STAT1-1 [cytosol] (Dictyostelium discoideum)

phospho-STAT1 [cytosol] (Bos taurus)

phospho-STAT1 [cytosol] (Canis familiaris)

phospho-STAT1 [cytosol] (Gallus gallus)

phospho-stat1a [cytosol] (Danio rerio)

phospho-dstB [cytosol] (Dictyostelium discoideum)

phospho-stat1 [cytosol] (Xenopus tropicalis)

phospho-Stat92E [cytosol] (Drosophila melanogaster)

phospho-dstA [cytosol] (Dictyostelium discoideum)

phospho-dstC [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O4'-phospho-L-tyrosine at 701

Coordinate

701

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-serine at 727

Coordinate

727

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_644671.1, NP_009330.1, XP_006712781.1

OpenTargets

ENSG00000115415

ZINC - Substances

STAT1_HUMAN

ZINC target

P42224

ZINC - Biogenic

STAT1_HUMAN

PRO

P42224

GlyGen

P42224

PDB

1YVL, 7NUF, 3WWT, 2KA6, 1BF5

ZINC - Investigational

STAT1_HUMAN

ZINC - Metabolites

STAT1_HUMAN

GeneCards

P42224

HPA

ENSG00000115415-STAT1

Ensembl

ENSP00000388240, ENSP00000386244, ENST00000361099, ENSP00000501164, ENST00000415035, ENSG00000115415, ENST00000409465, ENST00000540176, ENSP00000354394, ENST00000392322, ENST00000674080, ENSP00000438703, ENSP00000376136, ENSP00000501225, ENST00000673841

Pharos - Targets

P42224

ZINC - Predictions - Purchasable

STAT1_HUMAN

Orphanet

15563

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.89	16
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.852	8
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.774	7
UniProt:P23458 JAK1	6	p-Y1022,Y1023-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.757	6
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.706	6
UniProt:P15260 IFNGR1	2	p-Y440-IFNGR1 [plasma membrane] (R-HSA-873798) IFNGR1 [plasma membrane] (R-HSA-629623)	0.69	4
IntAct:EBI-9984951 IRF1			0.669	3
UniProt:Q8N9N8 EIF1A			0.666	4
UniProt:P42224 STAT1	7	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.643	4
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.623	4
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.576	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.571	3
UniProt:Q01804 OTUD4			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:Q13813 SPTAN1	6	SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [tertiary granule lumen] (R-HSA-6800874) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [specific granule lumen] (R-HSA-6799533)	0.547	2
UniProt:P03255-2			0.544	2
UniProt:P07239 DUSP			0.544	2
UniProt:Q05397 PTK2	11	p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) pY-PTK2 [cytosol] (R-HSA-9632393) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.536	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.536	6
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.532	4
UniProt:Q77M19 Q77M19			0.527	4
UniProt:Q997F2 V			0.527	2
UniProt:P0C1C7 W			0.527	2
UniProt:Q00978 IRF9	2	IRF9 [nucleoplasm] (R-HSA-913522) IRF9 [cytosol] (R-HSA-879183)	0.527	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P26664 POLG			0.524	5
IntAct:EBI-10097350 STAT			0.524	2
UniProt:Q4VW77 Q4VW77			0.524	2
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.524	2
UniProt:P03255-1			0.508	2
UniProt:P19793 RXRA	4	RXRA [cytosol] (R-HSA-9619757) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.508	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.508	2
UniProt:P17181 IFNAR1	2	IFNAR1 [plasma membrane] (R-HSA-877334) p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675)	0.499	2
UniProt:P48551 IFNAR2			0.499	2
IntAct:EBI-9825772 C-FOS PROMOTER REGION			0.499	3
IntAct:EBI-10097414 FOXP3			0.499	2
UniProt:P11277 SPTB	1	SPTB [cytosol] (R-HSA-391565)	0.488	2
UniProt:P27958-PRO_0000037576			0.463	4
UniProt:Q9UIV1 CNOT7	1	CNOT7 [cytosol] (R-HSA-429877)	0.463	2

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