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PXLP-AGXT2 [mitochondrial matrix]
Stable Identifier
R-HSA-904852
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
AGXT2, Alanine--glyoxylate aminotransferase 2, mitochondrial
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Homo sapiens)
AGXT2 tetramer [mitochondrial matrix] (Homo sapiens)
PXLP-AGXT2 [mitochondrial matrix] (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide catabolism (Homo sapiens)
Pyrimidine catabolism (Homo sapiens)
(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine (Homo sapiens)
AGXT2 tetramer [mitochondrial matrix] (Homo sapiens)
PXLP-AGXT2 [mitochondrial matrix] (Homo sapiens)
beta-alanine + pyruvate => 3-oxopropanoate + alanine (Homo sapiens)
AGXT2 tetramer [mitochondrial matrix] (Homo sapiens)
PXLP-AGXT2 [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
20018850
Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production
Lentz, SR
,
Rodionov, RN
,
Stevens, JW
,
Murry, DJ
,
Vaulman, SF
J Biol Chem
2010
External Reference Information
External Reference
UniProt:Q9BYV1 AGXT2
Gene Names
AGXT2, AGT2
Chain
transit peptide:1-41, chain:42-514
Reference Genes
BioGPS Gene:64902 AGXT2
COSMIC (genes):AGXT2 AGXT2
CTD Gene:64902 AGXT2
dbSNP Gene:64902 AGXT2
ENSEMBL:ENSG00000113492 AGXT2
HGNC:14412 AGXT2
KEGG:hsa:64902 AGXT2
Monarch:64902 AGXT2
NCBI Gene:64902 AGXT2
OMIM:612471 AGXT2
UCSC:Q9BYV1 AGXT2
Reference Transcript
RefSeq:NM_001306173.1 AGXT2
RefSeq:NM_031900.3 AGXT2
RefSeq:XM_017009748.1 AGXT2
Other Identifiers
11743920_a_at
11746944_a_at
16995155
229229_PM_at
229229_at
2853065
2853066
2853067
2853068
2853069
2853070
2853075
2853076
2853077
2853078
2853079
2853081
2853082
2853083
2853088
2853089
2853090
2853091
2853092
2853093
2853094
2853095
2853096
2853100
2853101
43594_at
58981_at
60480_at
64902
8111474
A_23_P156076
A_24_P63468
GE61644
GO:0003824
GO:0005739
GO:0005759
GO:0006520
GO:0006575
GO:0008453
GO:0008483
GO:0009436
GO:0016223
GO:0016740
GO:0019265
GO:0019481
GO:0030170
GO:0043226
GO:0045429
GO:0047305
GO:2001299
HMNXSV003012999
HMNXSV003057831
Hs.193228.0.S1_3p_at
ILMN_1783963
PH_hs_0011396
TC05001260.hg
Participates
as a component of
AGXT2 tetramer [mitochondrial matrix] (Homo sapiens)
Inferred To
agxt2 [mitochondrial matrix]
(Danio rerio)
agxt2 [mitochondrial matrix]
(Xenopus tropicalis)
Agxt2 [mitochondrial matrix]
(Mus musculus)
Agxt2 [mitochondrial matrix]
(Rattus norvegicus)
AGXT2 [mitochondrial matrix]
(Bos taurus)
AGXT2 [mitochondrial matrix]
(Canis familiaris)
AGXT2 [mitochondrial matrix]
(Sus scrofa)
Dmel\CG11241 [mitochondrial matrix]
(Drosophila melanogaster)
PXLP-AGXT2 [mitochondrial matrix]
(Caenorhabditis elegans)
PXLP-AGXT2 [mitochondrial matrix]
(Gallus gallus)
PXLP-AGXT2 [mitochondrial matrix]
(Schizosaccharomyces pombe)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 350
Coordinate
350
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
ENSEMBL
ENSP00000231420
,
ENSP00000479154
,
ENSP00000422799
,
ENST00000510428
,
ENST00000231420
,
ENST00000618015
OpenTargets
ENSG00000113492
IntEnz
2.6.1.44
HPA
ENSG00000113492-AGXT2
PRO
Q9BYV1
Pharos - Targets
Q9BYV1
HMDB Protein
HMDBP00396
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