Reactome | RHD gene produces PALM-C-Rhesus D protein

RHD gene produces PALM-C-Rhesus D protein

Stable Identifier

R-HSA-9038658

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleolus, plasma membrane

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RHD gene produces PALM-C-Rhesus D protein

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The RHD gene encodes the blood group Rh(D) polypeptide (Rhesus D protein, D antigen) (Bloy et al. 1988, Saboori et al. 1988, Avent et al. 1988). It is present only on the erythrocyte membrane as a post-translationally-modified palmitoylated protein (de Vetten & Agre 1988, Hartel-Schenk & Agre 1992).

Literature References

PubMed ID	Title	Journal	Year
3142870	The Rh polypeptide is a major fatty acid-acylated erythrocyte membrane protein de Vetten, MP, Agre, P	J. Biol. Chem.	1988
3131772	Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes Saboori, AM, Smith, BL, Agre, P	Proc. Natl. Acad. Sci. U.S.A.	1988
3135863	Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains Bloy, C, Blanchard, D, Dahr, W, Beyreuther, K, Salmon, C, Cartron, JP	Blood	1988
1544931	Mammalian red cell membrane Rh polypeptides are selectively palmitoylated subunits of a macromolecular complex Hartel-Schenk, S, Agre, P	J. Biol. Chem.	1992
3146980	Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane Avent, ND, Ridgwell, K, Mawby, WJ, Tanner, MJ, Anstee, DJ, Kumpel, B	Biochem. J.	1988