Reactome | RHD gene produces PALM-C-Rhesus D protein

RHD gene produces PALM-C-Rhesus D protein

Stable Identifier

R-HSA-9038658

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

nucleolus, plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

RHD gene produces PALM-C-Rhesus D protein

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The RHD gene encodes the blood group Rh(D) polypeptide (Rhesus D protein, D antigen) (Bloy et al. 1988, Saboori et al. 1988, Avent et al. 1988). It is present only on the erythrocyte membrane as a post-translationally-modified palmitoylated protein (de Vetten & Agre 1988, Hartel-Schenk & Agre 1992).

Literature References

PubMed ID	Title	Journal	Year
3131772	Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes Agre, P, Saboori, AM, Smith, BL	Proc. Natl. Acad. Sci. U.S.A.	1988
3142870	The Rh polypeptide is a major fatty acid-acylated erythrocyte membrane protein de Vetten, MP, Agre, P	J. Biol. Chem.	1988
3135863	Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains Beyreuther, K, Salmon, C, Blanchard, D, Dahr, W, Bloy, C, Cartron, JP	Blood	1988
1544931	Mammalian red cell membrane Rh polypeptides are selectively palmitoylated subunits of a macromolecular complex Agre, P, Hartel-Schenk, S	J. Biol. Chem.	1992
3146980	Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane Kumpel, B, Anstee, DJ, Mawby, WJ, Tanner, MJ, Avent, ND, Ridgwell, K	Biochem. J.	1988