miR-613 binds to the 3'UTR of the NR1H3 mRNA

Stable Identifier
R-HSA-9038545
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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miR-613 binds to the 3'UTR of the NR1H3 mRNA
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Translation of liver X receptor α (LXRα or NR1H3) mRNA is negatively regulated by microRNA 613 (miR-613), which binds directly to the specific miRNA response element (613MRE) within the 3'UTR of NR1H3 mRNA (Ou Z et al. 2011; Zhong D et al. 2013). The expression of miR-613 itself was induced upon the activation of NR1H3. However, miR-613 did not appear to be a direct NR1H3 target gene (Ou Z et al. 2011). Instead, the positive regulation of miR-613 by NR1H3 was mediated by the sterol regulatory element binding protein (SREBP)-1c, a known NR1H2,3 target gene (Ou Z et al. 2011). The binding of miR-613 to NR1H3 mRNA repressed lipogenesis in human liver carcinoma HepG2 cells and this was reversed by NR1H3 overexpression (Zhong D et al. 2013).

Literature References
PubMed ID Title Journal Year
21310851 MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation

Ou, Z, Wada, T, Gramignoli, R, Li, S, Strom, SC, Huang, M, Xie, W

Mol. Endocrinol. 2011
23496987 MicroRNA-613 represses lipogenesis in HepG2 cells by downregulating LXRα

Zhong, D, Zhang, Y, Zeng, YJ, Gao, M, Wu, GZ, Hu, CJ, Huang, G, He, FT

Lipids Health Dis 2013
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Authored
Shamovsky, V  (2018-01-19)
Reviewed
D'Eustachio, P  (2018-12-29)
Cummins, CL  (2019-08-09)
Repa, JJ  (2019-08-09)
Created
Shamovsky, V  (2018-03-06)