miR-613 binds to the 3'UTR of the NR1H3 mRNA

Stable Identifier
R-HSA-9038545
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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miR-613 binds to the 3'UTR of the NR1H3 mRNA
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Translation of liver X receptor α (LXRα or NR1H3) mRNA is negatively regulated by microRNA 613 (miR-613), which binds directly to the specific miRNA response element (613MRE) within the 3'UTR of NR1H3 mRNA (Ou Z et al. 2011; Zhong D et al. 2013). The expression of miR-613 itself was induced upon the activation of NR1H3. However, miR-613 did not appear to be a direct NR1H3 target gene (Ou Z et al. 2011). Instead, the positive regulation of miR-613 by NR1H3 was mediated by the sterol regulatory element binding protein (SREBP)-1c, a known NR1H2,3 target gene (Ou Z et al. 2011). The binding of miR-613 to NR1H3 mRNA repressed lipogenesis in human liver carcinoma HepG2 cells and this was reversed by NR1H3 overexpression (Zhong D et al. 2013).
Literature References
PubMed ID Title Journal Year
23496987 MicroRNA-613 represses lipogenesis in HepG2 cells by downregulating LXRα

Zhong, D, Zhang, Y, Zeng, YJ, Gao, M, Wu, GZ, Hu, CJ, Huang, G, He, FT

Lipids Health Dis 2013
21310851 MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation

Ou, Z, Wada, T, Gramignoli, R, Li, S, Strom, SC, Huang, M, Xie, W

Mol. Endocrinol. 2011
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Authored
Shamovsky, V  (2018-01-19)
Reviewed
D'Eustachio, P  (2018-12-29)
Cummins, CL  (2019-08-09)
Repa, JJ  (2019-08-09)
Created
Shamovsky, V  (2018-03-06)
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