Translation of liver X receptor α (LXRα or NR1H3) mRNA is negatively regulated by microRNA 613 (miR-613), which binds directly to the specific miRNA response element (613MRE) within the 3'UTR of NR1H3 mRNA (Ou Z et al. 2011; Zhong D et al. 2013). The expression of miR-613 itself was induced upon the activation of NR1H3. However, miR-613 did not appear to be a direct NR1H3 target gene (Ou Z et al. 2011). Instead, the positive regulation of miR-613 by NR1H3 was mediated by the sterol regulatory element binding protein (SREBP)-1c, a known NR1H2,3 target gene (Ou Z et al. 2011). The binding of miR-613 to NR1H3 mRNA repressed lipogenesis in human liver carcinoma HepG2 cells and this was reversed by NR1H3 overexpression (Zhong D et al. 2013).
Ou, Z, Wada, T, Gramignoli, R, Li, S, Strom, SC, Huang, M, Xie, W
Zhong, D, Zhang, Y, Zeng, YJ, Gao, M, Wu, GZ, Hu, CJ, Huang, G, He, FT
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