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miR-613 Nonendonucleolytic Minimal RISC [cytosol]
Stable Identifier
R-HSA-9038543
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
Argonaute1/3/4: miR-613
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Homo sapiens)
NR1H3 mRNA is translated (Homo sapiens)
NR1H3 mRNA:miR-613 RISC [cytosol] (Homo sapiens)
miR-613 RISC [cytosol] (Homo sapiens)
miR-613 Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-613 Nonendonucleolytic Minimal RISC [cytosol] (Homo sapiens)
miR-613 binds to the 3'UTR of the NR1H3 mRNA (Homo sapiens)
NR1H3 mRNA:miR-613 RISC [cytosol] (Homo sapiens)
miR-613 RISC [cytosol] (Homo sapiens)
miR-613 Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-613 Nonendonucleolytic Minimal RISC [cytosol] (Homo sapiens)
miR-613 RISC [cytosol] (Homo sapiens)
miR-613 Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-613 Nonendonucleolytic Minimal RISC [cytosol] (Homo sapiens)
General
The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.
Participants
components
miR-613 [cytosol]
(Homo sapiens)
Nonendonucleolytic Argonaute [cytosol]
(Homo sapiens)
Participates
as a component of
miR-613 Nonendonucleolytic RISC [cytosol] (Homo sapiens)
Inferred To
miR-613 Nonendonucleolytic Minimal RISC [cytosol]
(Bos taurus)
miR-613 Nonendonucleolytic Minimal RISC [cytosol]
(Canis familiaris)
miR-613 Nonendonucleolytic Minimal RISC [cytosol]
(Drosophila melanogaster)
miR-613 Nonendonucleolytic Minimal RISC [cytosol]
(Mus musculus)
miR-613 Nonendonucleolytic Minimal RISC [cytosol]
(Rattus norvegicus)
miR-613 Nonendonucleolytic Minimal RISC [cytosol]
(Sus scrofa)
miR-613 Nonendonucleolytic Minimal RISC [cytosol]
(Xenopus tropicalis)
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