ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators

Stable Identifier
Reaction [omitted]
Homo sapiens
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Rapid immunoprecipitation by mass spectrometry of endogenous proteins (RIME) analysis shows that in addition to interacting with PGR after progesterone stimulation, ESR1 also interacts with known co-activators NRIP, GATA3 and TLE3 (Mohammed et al, 2013; Mohammed et al, 2015). Progesterone treatment of breast cancer cell lines under estrogen-rich conditions promotes a redistribution of ER alpha binding to PGR binding sites. This redistribution coincides with co-occupancy of FOXA1 and EP300 at the novel binding sites as well as with the H3K27Ac mark, suggesting that the binding events are functional (Clarke et al, 2012; Mohammed et al, 2015).

Literature References
PubMed ID Title Journal Year
22545144 Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes

Clarke, CL, Graham, JD

PLoS ONE 2012
26153859 Progesterone receptor modulates ERĪ± action in breast cancer

Tarulli, GA, Hadfield, J, Birrell, SN, Perou, CM, Hickey, TE, Serandour, AA, Launchbury, R, Pugh, M, Silva, G, Russell, IA, Bruna, A, Stingl, J, Caldas, C, Raj, GV, D'Santos, C, Saadi, A, Mohammed, H, Rueda, OM, Serandour, AA, Robinson, JL, Tilley, WD, Brown, GD, Stark, R, Menon, S, Carroll, JS

Nature 2015
23403292 Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor

Ross-Innes, CS, D'Santos, C, Saadi, A, Palmieri, C, Mohammed, H, Atkins, A, Rueda, OM, Chin, SF, Serandour, AA, Holmes, KA, Ali, HR, Robinson, JL, Zwart, W, Stingl, J, Caldas, C, Brown, GD, Menon, S, Carroll, JS, Theodorou, V

Cell Rep 2013
Orthologous Events
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