Reactome | ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators

ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators

Stable Identifier

R-HSA-9038163

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators

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Rapid immunoprecipitation by mass spectrometry of endogenous proteins (RIME) analysis shows that in addition to interacting with PGR after progesterone stimulation, ESR1 also interacts with known co-activators NRIP, GATA3 and TLE3 (Mohammed et al, 2013; Mohammed et al, 2015). Progesterone treatment of breast cancer cell lines under estrogen-rich conditions promotes a redistribution of ER alpha binding to PGR binding sites. This redistribution coincides with co-occupancy of FOXA1 and EP300 at the novel binding sites as well as with the H3K27Ac mark, suggesting that the binding events are functional (Clarke et al, 2012; Mohammed et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
22545144	Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes Clarke, CL, Graham, JD	PLoS ONE	2012
26153859	Progesterone receptor modulates ERα action in breast cancer Mohammed, H, Russell, IA, Stark, R, Rueda, OM, Hickey, TE, Tarulli, GA, Serandour, AA, Serandour, AA, Birrell, SN, Bruna, A, Saadi, A, Menon, S, Hadfield, J, Pugh, M, Raj, GV, Brown, GD, D'Santos, C, Robinson, JL, Silva, G, Launchbury, R, Perou, CM, Stingl, J, Caldas, C, Tilley, WD, Carroll, JS	Nature	2015
23403292	Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor Mohammed, H, D'Santos, C, Serandour, AA, Ali, HR, Brown, GD, Atkins, A, Rueda, OM, Holmes, KA, Theodorou, V, Robinson, JL, Zwart, W, Saadi, A, Ross-Innes, CS, Chin, SF, Menon, S, Stingl, J, Palmieri, C, Caldas, C, Carroll, JS	Cell Rep	2013