NR1H3 gene transcription regulated by NR1H2,3

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R-HSA-9035281
Type
Reaction [omitted]
Species
Homo sapiens
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The liver X receptor alpha (LXRα or NR1H3) gene is transcribed to yield mRNA. The NR1H3 gene expression is auto-inducible ((Whitney KD et al. 2001; Laffitte BA et al. 2001; Li Y et al. 2002). NR1H3 (LXRα) induction was observed in multiple human cell types including monocyte-derived macrophages, the THP1 macrophage cell line and skin fibroblasts in response to NR1H3 and NR1H2 (LXRβ) ligands (20(S)hydroxycholesterol, 22(R)hydroxycholesterol, 24(S),25-epoxycholesterol,
GW3965 or T0901317) (Whitney KD et al. 2001; Laffitte BA et al. 2001; Li Y et al. 2002). This induction was mediated via LXR response elements (LXREs) found within the NR1H3 promoter ((Whitney KD et al 2001; Laffitte BA et al. 2001; Li Y et al. 2002). The autoregulatory loop led to the selective induction of NR1H3 gene expression whereas NR1H2 (LXRβ) was not induced (Whitney KD et al. 2001; Lafitte B et al. 2001; Li Y et al. 2002). The increased NR1H3 levels induce expression of its downstream target genes such as ABCA1, ABCG1 providing a simple yet exquisite mechanism for cells to respond to LXRs ligands and cholesterol loading (Li Y et al. 2002).

Literature References
PubMed ID Title Journal Year
11604492 Autoregulation of the human liver X receptor alpha promoter

Laffitte, BA, Joseph, SB, Walczak, R, Pei, L, Wilpitz, DC, Collins, JL, Tontonoz, P

Mol. Cell. Biol. 2001
11875109 Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism

Li, Y, Bolten, C, Bhat, BG, Woodring-Dietz, J, Li, S, Prayaga, SK, Xia, C, Lala, DS

Mol. Endocrinol. 2002
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