NR1H2,3 binds the EEPD1 gene

Stable Identifier
R-HSA-9035167
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
LXR binds the EEPD1 gene
ReviewStatus
5/5
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NR1H2,3 binds the EEPD1 gene
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Endonuclease-exonuclease-phosphatase family domain containing 1 (EEPD1/KIAA1706) was identiified as a direct transcriptional target of liver X receptors (LXR alpha (NR1H3) and LXR beta (NR1H2)) in murine bone marrow-derived macrophages (BMDM), J774 macrophages and in human monocyte-like THP-1 cells (Nelson JK et al. 2017). An LXR alpha (NR1H3) ChIP-seq study identified a LXR-response element (LXRE) in intron 2 of EEPD1 gene (Nelson JK et al. 2017; Feldmann R et al. 2013).
Literature References
PubMed ID Title Journal Year
28082258 EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux

Cook, EC, Nelson, JK, Koenis, DS, Zelcer, N, Lobaccaro, JA, Scheij, S, Baron, S, Moeton, M, Santos, A

Arterioscler. Thromb. Vasc. Biol. 2017
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Authored
Shamovsky, V  (2018-01-19)
Reviewed
D'Eustachio, P  (2018-12-29)
Repa, JJ  (2019-08-09)
Cummins, CL  (2019-08-09)
Created
Shamovsky, V  (2018-01-19)
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