RHOF GTPase cycle

Stable Identifier
R-HSA-9035034
Type
Pathway
Species
Homo sapiens
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This pathway catalogues RHOF (RIF) GTPase activator proteins (GAPs) and RHOF effectors. RHOF GTPase is thought to exist in the active GTP-bound state in the absence of any GEF activity (Tian et al. 2017). No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOF. RHOF is only found in vertebrates (Gad and Aspenstrom 2010; Fan and Mellor 2012). RHOF regulates cytoskeletal dynamics (Gad and Aspenstrom 2010; Aspenstrom et al. 2014) and promotes the formation of filopodia and stress fibers (Fan and Mellor 2012). RHOF may be involved in actin remodelling in lymphocyte microvilli (Fan and Mellor 2012). In neurons, RHOF contributes to the formation of dendritic spines (Fan and Mellor 2012).

Literature References
PubMed ID Title Journal Year
19818399 Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking

Gad, AK, Aspenström, P

Cell. Signal. 2010
24622787 Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics and membrane trafficking

Aspenström, P

Biol. Chem. 2014
28098758 Neurotrophin Promotes Neurite Outgrowth by Inhibiting Rif GTPase Activation Downstream of MAPKs and PI3K Signaling

Tian, X, Yan, H, Li, J, Wu, S, Wang, J, Fan, L

Int J Mol Sci 2017
22260703 The small Rho GTPase Rif and actin cytoskeletal remodelling

Fan, L, Mellor, H

Biochem. Soc. Trans. 2012
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