Based on the accepted model of PLCgamma1 (PLCG1) signaling, although this has not been tested in the context of the NTRK3 (TRKC) receptor-mediated activation of PLCG1, phosphorylated, active, PLCG1 dissociates from the receptor tyrosine kinase and catalyzes formation of DAG and IP3 second messengers (Carpenter and Ji 1999). Activation of rat Ntrk3 by human NTF3 (NT-3) is known to result in tyrosine phosphorylation of rat Plcg1 and activation of DAG and IP3 signaling (Marsh and Palfrey 1996).
Ji, Q, Carpenter, G
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