NTRK3 phosphorylates PLCG1

Stable Identifier
R-HSA-9034814
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Kinase activity of NTRK3 (TRKC) is needed for tyrosine phosphorylation and activation of PLCG1 in response to NTF3 (NT-3) (Guiton et al. 1995, Marsh and Palfrey 1996). NTRK3-mediated phosphorylation sites on PLCG1 have not been determined but are predicted to involve four tyrosine residues whose phosphorylation is known to be required for the phospholipase activity of PLCG1: Y472, Y771, Y783 and Y1253.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of NTF3:p-5Y-NTRK3 homodimer:PLCG1 [plasma membrane]
Physical Entity
Activity
Inferred From
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