NTRK3 phosphorylates PLCG1

Stable Identifier
R-HSA-9034814
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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NTRK3 phosphorylates PLCG1
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Kinase activity of NTRK3 (TRKC) is needed for tyrosine phosphorylation and activation of PLCG1 in response to NTF3 (NT-3) (Guiton et al. 1995, Marsh and Palfrey 1996). NTRK3-mediated phosphorylation sites on PLCG1 have not been determined but are predicted to involve four tyrosine residues whose phosphorylation is known to be required for the phospholipase activity of PLCG1: Y472, Y771, Y783 and Y1253.
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Catalyst Activity

protein tyrosine kinase activity of NTF3:p-5Y-NTRK3 homodimer:PLCG1 [plasma membrane]

Physical Entity
NTF3:p-5Y-NTRK3 homodimer:PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Ntrk3 phosphorylates Plcg1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-01-11)
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