NTF3 binds NTRK3

Stable Identifier
R-HSA-9034016
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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NTF3 binds NTRK3
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Neurtrophin-3 (NTF3, also known as NT-3) is the main ligand for the neuronal receptor tyrosine kinase NTRK3 (TRKC) (Lamballe et al. 1991). NTRK3 is not activated by other member of the neurotrophin family (NGF, BDNF and NTF4) (Lamballe et al. 1991, Ip et al. 1993). Binding to the NTF3 homodimer induces dimerization of the NTRK3 (TRKC) receptor, so that the stoichiometry of the ligand:receptor complex is 2:2 (Philo et al. 1994). In the study by Philo et al., a recombinant human NTF3 was used with a recombinant extracellular region of NTRK3, but the origin of NTRK3 was not specified.

Literature References
PubMed ID Title Journal Year
7961713 Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors

Philo, J, Talvenheimo, J, Wen, J, Rosenfeld, R, Welcher, A, Arakawa, T

J. Biol. Chem. 1994
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
positive regulation of neurotrophin TRK receptor signaling pathway (0051388)
Inferred From
NTF3 binds Ntrk3 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-01-02)