Reactome | Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix

Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix

Stable Identifier

R-HSA-9033514

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

peroxisomal membrane

ReviewStatus

5/5

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Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix

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The cargo protein bound to PEX7 is released from PEX7 into the peroxisomal matrix in a reaction that does not require ATP (Purdue et al. 1997, Dodt et al. 2001, Rodrigues et al. 2014, Rodrigues et al. 2015). PEX7 may also be released into the matrix (inferred from yeast in Nair et al. 2004), however later research indicates that PEX7 remains with PEX5L in the peroxisomal membrane (Rodrigues et al. 2015) apparently in a proteinaceous cavity (Dias et al. 2017). Mutations in PEX5 cause defects in import of PTS1-containing proteins or PTS2-containing proteins or both (Eberrink et al. 2009, Barøy et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
15545321	Pex7p translocates in and out of peroxisomes in Saccharomyces cerevisiae Nair, DM, Purdue, PE, Lazarow, PB	J. Cell Biol.	2004
9090383	Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor Purdue, PE, Zhang, JW, Skoneczny, M, Lazarow, PB	Nat. Genet.	1997
18712838	Genotype-phenotype correlation in PEX5-deficient peroxisome biogenesis defective cell lines Ebberink, MS, Mooyer, PA, Koster, J, Dekker, CJ, Eyskens, FJ, Dionisi-Vici, C, Clayton, PT, Barth, PG, Wanders, RJA, Waterham, HR	Hum. Mutat.	2009
24865970	A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway Rodrigues, TA, Alencastre, IS, Francisco, T, Brites, P, Fransen, M, Grou, CP, Azevedo, JE	Mol. Cell. Biol.	2014
26138649	Revisiting the intraperoxisomal pathway of mammalian PEX7 Rodrigues, TA, Grou, CP, Azevedo, JE	Sci Rep	2015
28765278	The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo Dias, AF, Rodrigues, TA, Pedrosa, AG, Barros-Barbosa, A, Francisco, T, Azevedo, JE	J. Biol. Chem.	2017
11546814	Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p Dodt, G, Warren, D, Becker, E, Rehling, P, Gould, SJ	J. Biol. Chem.	2001