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Ub-C11-PEX5L [cytosol]
Stable Identifier
R-HSA-9033510
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Peroxisomal targeting signal 1 receptor, PEX5_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)
Ub:PEX5L [cytosol] (Homo sapiens)
Ub-C11-PEX5L [cytosol] (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)
Ub:PEX5S,L [cytosol] (Homo sapiens)
Ub:PEX5L [cytosol] (Homo sapiens)
Ub-C11-PEX5L [cytosol] (Homo sapiens)
USP9X binds Ub:PEX5L (Homo sapiens)
USP9X:Ub:PEX5L [cytosol] (Homo sapiens)
Ub:PEX5L [cytosol] (Homo sapiens)
Ub-C11-PEX5L [cytosol] (Homo sapiens)
Ub:PEX5L [cytosol] (Homo sapiens)
Ub-C11-PEX5L [cytosol] (Homo sapiens)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)
USP9X:Ub:PEX5L [cytosol] (Homo sapiens)
Ub:PEX5L [cytosol] (Homo sapiens)
Ub-C11-PEX5L [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50542-1 PEX5
Gene Names
PEX5, PXR1
Other Identifiers
11719618_a_at
11741493_a_at
16747770
203244_PM_at
203244_at
215481_PM_s_at
215481_s_at
2465572
2465576
3403300
3403301
3403302
3403303
3403305
3403306
3403307
3403309
3403310
3403311
3403316
3403317
3403319
3403321
3403322
3403323
3403324
3403325
3403326
3403327
3403328
3403329
3403330
3403332
40151_s_at
40152_r_at
5830
7953651
A_23_P48246
A_24_P372932
GE60411
GO:0000038
GO:0000268
GO:0000425
GO:0001764
GO:0005052
GO:0005515
GO:0005737
GO:0005739
GO:0005777
GO:0005778
GO:0005782
GO:0005794
GO:0005829
GO:0006625
GO:0006629
GO:0006635
GO:0006886
GO:0006914
GO:0007005
GO:0007006
GO:0007029
GO:0007031
GO:0015031
GO:0016020
GO:0016558
GO:0016560
GO:0016561
GO:0016562
GO:0019899
GO:0021795
GO:0021895
GO:0030154
GO:0031267
GO:0031333
GO:0032991
GO:0033328
GO:0034614
GO:0040018
GO:0043226
GO:0044255
GO:0044721
GO:0045046
GO:0048468
GO:0048856
GO:0048870
GO:0050877
GO:0050905
GO:0051262
GO:0055085
GO:0061024
GO:0065003
GO:0140104
GO:0140597
HMNXSV003030185
HMNXSV003058153
Hs.158084.1.A1_3p_a_at
ILMN_1660232
PH_hs_0029792
TC12000109.hg
U35407_at
Z48054_at
g4506346_3p_at
Participates
as a component of
Ub:PEX5L [cytosol] (Homo sapiens)
Other forms of this molecule
PEX5 isoform L [cytosol]
Ub-C11-PEX5L [peroxisomal membrane]
PEX5 isoform L [peroxisomal membrane]
Inferred To
Pex5 [cytosol]
(Drosophila melanogaster)
Pex5 [cytosol]
(Mus musculus)
Pex5 [cytosol]
(Rattus norvegicus)
Ub-C11-PEX5L [cytosol]
(Gallus gallus)
prx-5 [cytosol]
(Caenorhabditis elegans)
PEX5 [cytosol]
(Bos taurus)
PEX5 [cytosol]
(Canis familiaris)
PEX5 [cytosol]
(Saccharomyces cerevisiae)
PEX5 [cytosol]
(Sus scrofa)
pex5 [cytosol]
(Dictyostelium discoideum)
pex5 [cytosol]
(Schizosaccharomyces pombe)
pex5 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 11
Coordinate
11
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
XP_011519101.1
,
XP_016875238.1
,
XP_011519097.1
,
XP_016875243.1
,
NP_001124495.1
,
XP_011519102.1
,
XP_016875244.1
,
XP_016875241.1
,
NP_001124498.1
,
NP_001124497.1
,
NP_001287718.1
,
XP_016875239.1
,
XP_016875242.1
,
XP_011519099.1
,
XP_011519100.1
,
NP_001124496.1
,
NP_000310.2
,
XP_016875237.1
OpenTargets
ENSG00000139197
GeneCards
P50542
HPA
ENSG00000139197-PEX5
Ensembl
ENSP00000407401
,
ENST00000420616
,
ENSP00000499823
,
ENSP00000266563
,
ENSP00000266564
,
ENSP00000500509
,
ENSP00000502374
,
ENSP00000500043
,
ENSP00000500230
,
ENSG00000288217
,
ENST00000266564
,
ENST00000266563
,
ENSP00000400647
,
ENSP00000500696
,
ENST00000675855
,
ENST00000455147
,
ENST00000672541
,
ENST00000672694
,
ENSG00000139197
,
ENST00000672776
,
ENST00000672242
,
ENSP00000410159
,
ENST00000671993
,
ENST00000434354
PRO
P50542
Pharos - Targets
P50542
Orphanet
16646
PDB
2C0M
,
4KYO
,
7Z0K
,
4KXK
,
4BXU
,
2W84
,
2C0L
,
2J9Q
,
1FCH
,
3R9A
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75381 PEX14
2
PEX14 [cytosol]
(R-HSA-9603806)
PEX14 [peroxisomal membrane]
(R-HSA-9033101)
0.807
13
UniProt:O00623 PEX12
2
PEX12 [cytosol]
(R-HSA-9603782)
PEX12 [peroxisomal membrane]
(R-HSA-8953911)
0.683
4
UniProt:P07195 LDHB
1
LDHB [cytosol]
(R-HSA-70503)
0.556
3
UniProt:EP400NL H9KV84
0.556
3
UniProt:Q9NZ81 PRR13
0.556
3
UniProt:Q49A88 CCD14
0.556
3
UniProt:Q6NSB6 Q6NSB6
0.556
3
UniProt:A8K3Q9 A8K3Q9
0.556
3
UniProt:Q8N5N8 Q8N5N8
0.556
3
UniProt:Q75MR5 Q75MR5
0.556
3
UniProt:Q6IPH7 Q6IPH7
0.556
3
UniProt:Q68DY9 ZNF772
1
ZNF772 [nucleoplasm]
(R-HSA-3110231)
0.556
3
UniProt:P06703 S10A6
0.556
3
UniProt:Q6IMN6 CAPR2
0.556
3
UniProt:O14734 ACOT8
2
ACOT8 [cytosol]
(R-HSA-9033134)
ACOT8 [peroxisomal matrix]
(R-HSA-193426)
0.556
3
UniProt:Q8WTR4 GDPD5
1
GDPD5 [endoplasmic reticulum membrane]
(R-HSA-6814136)
0.556
3
UniProt:Q9BSI4 TINF2
1
TINF2 [nucleoplasm]
(R-HSA-174883)
0.508
2
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