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TYSND1 cleaves PHYH
Stable Identifier
R-HSA-9033490
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
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Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
TYSND1 cleaves peroxisomal proteins (Homo sapiens)
TYSND1 cleaves PHYH (Homo sapiens)
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The trypsin-like serine-type endopeptidase TYSND1 cleaves PHYH between amino acid residues 30 and 31, yielding PHYH(1-30) and PHYH(31-338). In mice, knockout of Tysnd1 causes reduced localization of Phyh to peroxisomes.
Participants
Input
H2O [peroxisomal matrix]
PHYH(1-338) [peroxisomal matrix]
(Homo sapiens)
Output
PHYH [peroxisomal matrix]
(Homo sapiens)
PHYH(1-30) [peroxisomal matrix]
(Homo sapiens)
Participates
as an event of
TYSND1 cleaves peroxisomal proteins (Homo sapiens)
Catalyst Activity
serine-type endopeptidase activity of TYSND1 [peroxisomal matrix]
Physical Entity
TYSND1 [peroxisomal matrix]
(Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Tysnd1 cleaves Phyh (Mus musculus)
Authored
May, B (2017-12-22)
Reviewed
Van Veldhoven, PP (2018-02-13)
Fransen, M (2018-02-13)
Azevedo, JE (2018-03-12)
Created
May, B (2017-12-22)
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