NTRK2 and CDK5 promote activation of RAC1 by TIAM1

Stable Identifier
R-HSA-9033292
Type
Reaction
Species
Homo sapiens
Compartment
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TIAM1, activated by binding to CDK5-phosphorylated and BDNF-activated NTRK2 (TRKB), promotes guanine nucleotide exchange on RAC1, which results in formation of the active RAC1:GTP complex (Lai et al. 2012).

Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of BDNF:p-5Y,S479-NTRK2:p-Y829-TIAM1 [plasma membrane]

Inferred From
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