Reactome | PEX5 [cytosol]

PEX5 [cytosol]

Stable Identifier

R-HSA-9033132

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peroxisomal targeting signal 1 receptor, PEX5_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q68DY9 ZNF772

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External Reference Information

External Reference

UniProt:P50542 PEX5

Gene Names

PEX5, PXR1

Chain

chain:1-639

Reference Genes

BioGPS Gene:5830 PEX5

COSMIC (genes):PEX5 PEX5

CTD Gene:5830 PEX5

dbSNP Gene:5830 PEX5

ENSEMBL:ENSG00000139197 PEX5

ENSEMBL_homo_sapiens_GENE:ENSG00000139197.11 PEX5

ENSEMBL_homo_sapiens_GENE:ENSG00000288217.3 PEX5

HGNC:9719 PEX5

KEGG Gene (Homo sapiens):5830 PEX5

Monarch:5830 PEX5

NCBI Gene:5830 PEX5

OMIM:600414 PEX5

UCSC:P50542 PEX5

Reference Transcript

Other Identifiers

11719618_a_at

11741493_a_at

16747770

203244_PM_at

203244_at

215481_PM_s_at

215481_s_at

2465572

2465576

3403300

3403301

3403302

3403303

3403305

3403306

3403307

3403309

3403310

3403311

3403316

3403317

3403319

3403321

3403322

3403323

3403324

3403325

3403326

3403327

3403328

3403329

3403330

3403332

40151_s_at

40152_r_at

5830

7953651

A_23_P48246

A_24_P372932

GE60411

GO:0000038

GO:0000268

GO:0000425

GO:0001764

GO:0005052

GO:0005515

GO:0005737

GO:0005739

GO:0005777

GO:0005778

GO:0005782

GO:0005794

GO:0005829

GO:0006625

GO:0006629

GO:0006635

GO:0006886

GO:0006914

GO:0007005

GO:0007006

GO:0007029

GO:0007031

GO:0015031

GO:0016020

GO:0016558

GO:0016560

GO:0016561

GO:0016562

GO:0019899

GO:0021795

GO:0021895

GO:0030154

GO:0031267

GO:0031333

GO:0032991

GO:0033328

GO:0034614

GO:0040018

GO:0043226

GO:0044255

GO:0044721

GO:0045046

GO:0048468

GO:0048856

GO:0048870

GO:0050877

GO:0050905

GO:0051262

GO:0055085

GO:0061024

GO:0065003

GO:0140104

GO:0140597

HMNXSV003030185

HMNXSV003058153

Hs.158084.1.A1_3p_a_at

ILMN_1660232

PH_hs_0029792

TC12000109.hg

U35407_at

Z48054_at

g4506346_3p_at

Participates

as an input of

ATM binds PEX5 (Homo sapiens)

as a component of

ATM:PEX5 [cytosol] (Homo sapiens)

Other forms of this molecule

p-PEX5 [peroxisomal membrane]

Ub-p-PEX5 [peroxisomal membrane]

PEX5 [peroxisomal membrane]

Inferred To

Pex5 [cytosol] (Drosophila melanogaster)

Pex5 [cytosol] (Mus musculus)

Pex5 [cytosol] (Rattus norvegicus)

PEX5 [cytosol] (Bos taurus)

PEX5 [cytosol] (Canis familiaris)

PEX5 [cytosol] (Saccharomyces cerevisiae)

PEX5 [cytosol] (Sus scrofa)

PEX5 isoform L [cytosol] (Gallus gallus)

pex5 [cytosol] (Dictyostelium discoideum)

pex5 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_016875237.1, XP_016875242.1, NP_001124495.1, XP_011519100.1, XP_011519097.1, XP_011519101.1, NP_001124497.1, NP_001124498.1, XP_016875243.1, XP_016875238.1, XP_011519102.1, NP_000310.2, XP_016875239.1, XP_011519099.1, XP_016875241.1, NP_001124496.1, NP_001287718.1, XP_016875244.1

OpenTargets

ENSG00000139197

GeneCards

P50542

HPA

ENSG00000139197-PEX5

Ensembl

ENST00000672776, ENST00000671993, ENST00000672541, ENST00000672694, ENST00000672242, ENST00000266564, ENSP00000266563, ENSP00000407401, ENSG00000139197, ENSP00000266564, ENST00000434354, ENSP00000500696, ENSP00000410159, ENST00000455147, ENST00000675855, ENSP00000500230, ENSP00000400647, ENSP00000500043, ENSP00000499823, ENST00000266563, ENST00000420616, ENSG00000288217, ENSP00000500509, ENSP00000502374

PRO

P50542

Pharos - Targets

P50542

Orphanet

16646

PDB

4KXK, 4BXU, 2C0L, 2W84, 7Z0K, 2J9Q, 4KYO, 2C0M, 3R9A, 1FCH

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75381 PEX14	2	PEX14 [cytosol] (R-HSA-9603806) PEX14 [peroxisomal membrane] (R-HSA-9033101)	0.807	13
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.683	4
UniProt:P07195 LDHB	1	LDHB [cytosol] (R-HSA-70503)	0.556	3
UniProt:EP400NL H9KV84			0.556	3
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:Q49A88 CCD14			0.556	3
UniProt:Q6NSB6 Q6NSB6			0.556	3
UniProt:A8K3Q9 A8K3Q9			0.556	3
UniProt:Q8N5N8 Q8N5N8			0.556	3
UniProt:Q75MR5 Q75MR5			0.556	3
UniProt:Q6IPH7 Q6IPH7			0.556	3
UniProt:Q68DY9 ZNF772	1	ZNF772 [nucleoplasm] (R-HSA-3110231)	0.556	3
UniProt:P06703 S10A6			0.556	3
UniProt:Q6IMN6 CAPR2			0.556	3
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.556	3
UniProt:Q8WTR4 GDPD5	1	GDPD5 [endoplasmic reticulum membrane] (R-HSA-6814136)	0.556	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2

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