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AGXT [cytosol]
Stable Identifier
R-HSA-9033128
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine--pyruvate aminotransferase, SPYA_HUMAN
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
AGXT [cytosol] (Homo sapiens)
PEX5S,L binds cargo proteins containing PTS1 (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
AGXT [cytosol] (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
AGXT [cytosol] (Homo sapiens)
PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
AGXT [cytosol] (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo protein [cytosol] (Homo sapiens)
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
AGXT [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21549 AGXT
Gene Names
AGXT, AGT1, SPAT
Chain
chain:1-392
Reference Genes
BioGPS Gene:189 AGXT
COSMIC (genes):AGXT AGXT
CTD Gene:189 AGXT
dbSNP Gene:189 AGXT
ENSEMBL:ENSG00000172482 AGXT
ENSEMBL_homo_sapiens_GENE:ENSG00000172482.5 AGXT
HGNC:341 AGXT
KEGG Gene (Homo sapiens):189 AGXT
Monarch:189 AGXT
NCBI Gene:189 AGXT
OMIM:604285 AGXT
UCSC:P21549 AGXT
Reference Transcript
RefSeq:NM_000030.2 AGXT
Other Identifiers
11731623_s_at
11762478_at
16893287
189
206957_PM_at
206957_at
210326_PM_at
210326_at
210327_PM_s_at
210327_s_at
2535978
2535979
2535981
2535983
2535985
2535986
2535989
2535990
2535991
2535995
2535996
2535997
2535998
2535999
37880_at
8049737
A_23_P83590
A_33_P3250278
GE502660
GO:0003824
GO:0004760
GO:0005515
GO:0005777
GO:0005782
GO:0005829
GO:0006520
GO:0006563
GO:0006790
GO:0007219
GO:0008453
GO:0008483
GO:0009436
GO:0016597
GO:0016740
GO:0019265
GO:0019448
GO:0023052
GO:0030170
GO:0042802
GO:0042803
GO:0042853
GO:0043226
GO:0043231
GO:0043621
GO:0046487
GO:0046724
HMNXSV003011348
ILMN_1709796
PH_hs_0008554
TC02001471.hg
X53414_at
g219432_3p_s_at
g7706736_3p_at
Participates
as a member of
Cargo proteins containing PTS1 [cytosol] (Homo sapiens)
Other forms of this molecule
PXLP-AGXT [peroxisomal matrix]
Inferred To
AGXT [cytosol]
(Bos taurus)
AGXT [cytosol]
(Caenorhabditis elegans)
AGXT [cytosol]
(Canis familiaris)
AGXT [cytosol]
(Dictyostelium discoideum)
AGXT [cytosol]
(Drosophila melanogaster)
AGXT [cytosol]
(Gallus gallus)
AGXT [cytosol]
(Mus musculus)
AGXT [cytosol]
(Rattus norvegicus)
AGXT [cytosol]
(Sus scrofa)
AGXT [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000021.1
OpenTargets
ENSG00000172482
IntEnz
2.6.1.51
,
2.6.1.44
HPA
ENSG00000172482-AGXT
GeneCards
P21549
Ensembl
ENSP00000302620
,
ENSG00000172482
,
ENST00000307503
PRO
P21549
Pharos - Targets
P21549
Orphanet
15476
HMDB Protein
HMDBP00789
PDB
6RV1
,
5OG0
,
4KXK
,
2YOB
,
6RV0
,
1H0C
,
5LUC
,
4KYO
,
5HHY
,
1J04
,
7NS7
,
4I8A
,
5F9S
,
4CBR
,
3R9A
,
4CBS
,
5OFY
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50542-1 PEX5
4
Ub-C11-PEX5L [cytosol]
(R-HSA-9033510)
PEX5 isoform L [cytosol]
(R-HSA-9033103)
Ub-C11-PEX5L [peroxisomal membrane]
(R-HSA-9033501)
PEX5 isoform L [peroxisomal membrane]
(R-HSA-9033489)
0.655
4
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:Q6DKK2 TTC19
1
TTC19 [mitochondrial inner membrane]
(R-HSA-9906047)
0.556
3
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