NTRK2 phosphorylates CDK5

Stable Identifier
R-HSA-9032854
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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NTRK2 phosphorylates CDK5
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BDNF-activated NTRK2 (TRKB) phosphorylates CDK5 on tyrosine residue Y15, thus increasing CDK5 catalytic activity (Cheung et al. 2007).

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of BDNF:p-5Y-NTRK2 homodimer:CDK5:p35 [plasma membrane]
Physical Entity
BDNF:p-5Y-NTRK2 homodimer:CDK5:p35 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Ntrk2 phosohorylates CDK5 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-19)