DOCK3-mediated activation of RAC1 downstream of BDNF-induced signaling by NTRK2 (TRKB) plays a role in axonal growth and regeneration. DOCK3 can be recruited to the plasma membrane to activate RAC1 by binding to NTRK-associated FYN (Namekata et al. 2010). Alternatively, DOCK3 can, upon poorly elucidated RHOG activation by the BDNF:NTRK2 complex, bind to the RHOG:GTP complex and activate RAC1 in an ELMO1-dependent manner (Namekata et al. 2012).
Harada, T, Namekata, K, Guo, X, Harada, C, Parada, LF, Kimura, H, Taya, C
Harada, T, Watanabe, H, Namekata, K, Kimura, A, Guo, X, Harada, C, Kawamura, K, Kittaka, D
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