NTRK2 activates RAC1

Stable Identifier
R-HSA-9032759
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Pathway
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Homo sapiens
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DOCK3-mediated activation of RAC1 downstream of BDNF-induced signaling by NTRK2 (TRKB) plays a role in axonal growth and regeneration. DOCK3 can be recruited to the plasma membrane to activate RAC1 by binding to NTRK-associated FYN (Namekata et al. 2010). Alternatively, DOCK3 can, upon poorly elucidated RHOG activation by the BDNF:NTRK2 complex, bind to the RHOG:GTP complex and activate RAC1 in an ELMO1-dependent manner (Namekata et al. 2012).

Literature References
PubMed ID Title Journal Year
20368433 Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex

Harada, T, Namekata, K, Guo, X, Harada, C, Parada, LF, Kimura, H, Taya, C

Proc. Natl. Acad. Sci. U.S.A. 2010
22734669 Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG

Harada, T, Watanabe, H, Namekata, K, Kimura, A, Guo, X, Harada, C, Kawamura, K, Kittaka, D

Genes Cells 2012
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GlyCosmos
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