FYN-mediated phosphorylation of GRIN2B

Stable Identifier
R-HSA-9032601
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Kinase activity of FYN is needed for tyrosine phosphorylation of the GRIN2B (also known as NR2B or GluN2B) subunit of the NMDA receptor complex in response to BDNF-mediated activation of the NTRK2 (TRKB) receptor (Mizuno et al. 2003, Li et al. 2017). The exact stoichiometry of this reaction and involvement of other proteins is not known.

Based on studies in rats, phosphorylation of GRIN2B by FYN downstream of NTRK2 signaling plays an important role in long term potentiation (LTP) and spatial memory formation (Mizuno et al. 2003) as well as in spinal LTP and pain hypersensitivity after peripheral nerve injury (Li et al. 2017).

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Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:GRIN2B [plasma membrane]
Physical Entity
Activity
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Created