NTRK2-bound FYN autophosphorylates

Stable Identifier
R-HSA-9032532
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NTRK2-bound FYN autophosphorylates
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Upon binding to BDNF-activated NTRK2 (TRKB) receptor, autophosphorylation of FYN at tyrosine residue Y420 increases (Mizuno et al. 2003). The exact stoichiometry and involvement of other proteins is not known.

Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of BDNF:p-5Y-NTRK2 homodimer:MyrG-FYN-1 [plasma membrane]

Physical Entity
BDNF:p-5Y-NTRK2 homodimer:MyrG-FYN-1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Ntrk2-bound Fyn autophosphorylates (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-14)
Cite Us!