Reactome | MyrG-FYN-1 [plasma membrane]

MyrG-FYN-1 [plasma membrane]

Stable Identifier

R-HSA-9032506

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

MyrG-FYN-B, MyrG-FynB, Brain-specific FYN isoform

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Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
20176329	[Neuronal isoforms of Src, Fyn and Lck tyrosine kinases: A specific role for p56lckN in neuron protection] Rouer, E	C. R. Biol.	2010

External Reference Information

External Reference

UniProt:P06241-1 FYN

Gene Names

FYN

Participates

as an input of

Activated NTRK2 binds FYN (Homo sapiens)

as a component of

BDNF:p-5Y-NTRK2 homodimer:MyrG-FYN-1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

MyrG-p-Y420-FYN-1 [plasma membrane]

Modified Residues

Name

N-myristoylglycine at 2

Coordinate

PsiMod Name

N-myristoylglycine [MOD:00068]

PsiMod Definition

A protein modification that effectively converts a glycine residue to N-myristoylglycine.

Cross References

RefSeq

XP_016866143.1, XP_005266947.1, XP_016866141.1, NP_694593.1, NP_694592.1, XP_005266949.1, XP_016866140.1, XP_016866139.1, NP_002028.1, XP_016866142.1

Guide to Pharmacology - Targets

2026

OpenTargets

ENSG00000010810

ENSEMBL

ENSG00000010810, ENSP00000357667, ENST00000354650, ENSP00000357656, ENST00000368667, ENSP00000346671, ENSP00000357671, ENST00000368678, ENST00000368682, ENSP00000229471, ENST00000229471

ZINC - FDA approved

FYN_HUMAN

ZINC - Substances

FYN_HUMAN

ZINC - Biogenic

FYN_HUMAN

ZINC target

P06241

PRO

P06241

GlyGen

P06241

PDB

5ZAU, 7UD6, 1G83, 4U17, 6EDF, 7A2P, 6IPZ, 7A2X, 2MRJ, 3H0F, 1SHF, 7A2J, 7A2T, 7A2U, 7A2L, 7A2V, 4U1P, 7A2N, 7A2W, 1AOU, 1NYF, 1NYG, 2MQI, 1A0N, 8KDX, 4ZNX, 1AZG, 2DQ7, 3UA6, 4D8D, 4EIK, 7A2Q, 6IPY, 1EFN, 7A2S, 7A2Y, 2MRK, 7A2R, 1ZBJ, 7A2K, 7A2Z, 3H0H, 7A2M, 1AVZ, 3H0I, 7A2O, 3UA7, 1AOT, 1FYN, 1M27

ZINC - Investigational

FYN_HUMAN

ZINC - Metabolites

FYN_HUMAN

IntEnz

2.7.10.2

HPA

ENSG00000010810-FYN

GeneCards

FYN

Pharos - Targets

P06241

ZINC - Predictions - Purchasable

FYN_HUMAN

HMDB Protein

HMDBP01322

Interactors (75)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.848	8
UniProt:O15117 FYB	1	FYB [cytosol] (R-HSA-390925)	0.819	7
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.8	8
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.798	6
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.744	6
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.74	6
UniProt:Q05655 PRKCD	12	PRKCD [cytosol] (R-HSA-58200) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD(330-676) [cytosol] (R-HSA-212551) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) p-T507-PRKCD [cytosol] (R-HSA-5218746) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-676) [nucleoplasm] (R-HSA-450606)	0.737	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.723	5
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.722	3
UniProt:P56945 BCAR1	4	BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645)	0.716	4
UniProt:Q14289 PTK2B	3	PTK2B [cytosol] (R-HSA-5218721) PTK2B [cytosol] (R-HSA-390932) p-Y-PTK2B [cytosol] (R-HSA-508515)	0.702	5
UniProt:P27958 POLG	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.697	4
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.696	4
UniProt:P10636-6 MAPT			0.676	3
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.671	6
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.669	5
UniProt:P54253 ATX1			0.666	8
UniProt:O43281 EFS			0.666	4
UniProt:Q04759 PRKCQ	9	p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) PRKCQ [plasma membrane] (R-HSA-202346) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [cytosol] (R-HSA-58216) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ(1-354) [cytosol] (R-HSA-212526) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ [photoreceptor disc membrane] (R-HSA-2648997)	0.66	7
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.643	3
UniProt:P50406 HTR6	1	HTR6 [plasma membrane] (R-HSA-390956)	0.633	7
UniProt:A7KAX9 ARHGAP32	1	ARHGAP32 [cytosol] (R-HSA-195134)	0.633	4
UniProt:P10636-2 MAPT			0.623	2
UniProt:Q9NWQ8 PAG1	2	PAG1 [plasma membrane] (R-HSA-180500) p-Y317-PAG1 [plasma membrane] (R-HSA-180494)	0.623	5
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.609	3
UniProt:O92972 POLG			0.589	2
UniProt:Q9WMX2 POLG			0.589	2
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.589	2
UniProt:P10636 MAPT	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.589	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.581	9
UniProt:Q9NZQ3 NCKIPSD	1	NCKIPSD [cytosol] (R-HSA-2197671)	0.573	2
UniProt:P03407 NEF			0.573	3
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.573	2
UniProt:P06729 CD2	1	CD2 [plasma membrane] (R-HSA-197795)	0.572	3
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.571	2
UniProt:Q86UR5 RIMS1	1	RIMS1 [cytosol] (R-HSA-210407)	0.564	2
UniProt:Q9WU82	11	phospho-Ctnnb1 [nucleoplasm] (R-RNO-3134926) phospho-Ctnnb1 [cytosol] (R-RNO-3134933) Ctnnb1 [plasma membrane] (R-RNO-9038440) phospho-Ctnnb1 [cytosol] (R-RNO-8942363) phospho-Ctnnb1 [cytosol] (R-RNO-8942367) phospho-Ctnnb1 [cytosol] (R-RNO-8942369) phospho-Ctnnb1 [cytosol] (R-RNO-8942374) Ctnnb1 [cytosol] (R-RNO-202950) Ctnnb1 [cytosol] (R-RNO-202930) Ctnnb1 [cytosol] (R-RNO-448839) Ctnnb1 [nucleoplasm] (R-RNO-3451168)	0.564	2
UniProt:Q9HCN6 GP6	1	GP6 [plasma membrane] (R-HSA-114574)	0.564	2
UniProt:P02751-7 FN1			0.558	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.558	2
UniProt:Q2GHU2 Q2GHU2			0.557	4
UniProt:P35520 CBS	1	PXLP-K119-CBS [cytosol] (R-HSA-1614563)	0.556	3
UniProt:Q9NZ42 PSENEN	2	PSENEN [plasma membrane] (R-HSA-157331) PSENEN [endosome membrane] (R-HSA-9010101)	0.556	3
UniProt:P30519 HMOX2	3	HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [plasma membrane] (R-HSA-6799676)	0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.556	3
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.556	3
UniProt:Q96BI3 APH1A	2	APH1A [plasma membrane] (R-HSA-3211581) APH1A [endosome membrane] (R-HSA-9010105)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
IntAct:EBI-25857140 ORF			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:P23560-2 BDNF			0.556	3
UniProt:P00491 PNP	7	PNP [ficolin-1-rich granule lumen] (R-HSA-6803278) PNP [extracellular region] (R-HSA-6806505) PNP [secretory granule lumen] (R-HSA-6803318) PNP [cytosol] (R-HSA-61933) PNP D128G [cytosol] (R-HSA-9735785) PNP E89K [cytosol] (R-HSA-9735781) PNP R234P [cytosol] (R-HSA-9735772)	0.556	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P99999 CYCS	6	CYCS [cytosol] (R-HSA-53259) CYCS [mitochondrial intermembrane space] (R-HSA-114244) apo-CYCS [mitochondrial inner membrane] (R-HSA-352608) Cytochrome c (reduced) [mitochondrial inner membrane] (R-HSA-352609) Cytochrome c (oxidised) [mitochondrial inner membrane] (R-HSA-352607) AcK-CYCS [mitochondrial intermembrane space] (R-HSA-5688308)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.547	2
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-5Y-PTK2 [cytosol] (R-HSA-5218711) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.547	3
UniProt:O75563 SKAP2	1	SKAP2 [cytosol] (R-HSA-390927)	0.547	2
UniProt:P10636-5 MAPT			0.544	2
UniProt:Q58FF6 H90B4			0.527	3
UniProt:P31424-2 GRM5			0.524	2
UniProt:Q9HCN6-1 GP6			0.524	2
UniProt:O14559 ARHGAP33	1	ARHGAP33 [cytosol] (R-HSA-3604399)	0.508	2
UniProt:Q8BHK6	1	Slamf7 [plasma membrane] (R-MMU-3006369)	0.499	2
UniProt:P61980	2	Hnrnpk [nucleoplasm] (R-RNO-4570532) Hnrnpk [nucleoplasm] (R-RNO-71945)	0.469	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	2

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