LTA4 translocates from neutrophil cytosol to platelet cytosol

Stable Identifier
R-HSA-9032036
Type
Reaction [uncertain]
Species
Homo sapiens
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Leukotriene A4 (LTA4), produced by 5-lipoxygenase (ALOX5) in neutrophils, can be taken up by platelets where it is acted upon by 12-lipoxygenase (ALOX12) to form lipoxins (Samuelsson et al. 1987). The mechanism of translocation is unknown.

Literature References
PubMed ID Title Journal Year
2820055 Leukotrienes and lipoxins: structures, biosynthesis, and biological effects

Samuelsson, B, Dahlén, SE, Lindgren, JA, Rouzer, CA, Serhan, CN

Science 1987
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