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NTRK2-phosphorylated FRS2 binds PTPN11
Stable Identifier
R-HSA-9031981
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through FRS2 and FRS3 (Homo sapiens)
NTRK2-phosphorylated FRS2 binds PTPN11 (Homo sapiens)
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Protein tyrosine phosphatase PTPN11 (SHP2) binds to FRS2 (also known as FRS2alpha or STN1) upon phosphorylation of FRS2 by activated NTRK2 (TRKB) (Easton et al. 2006).
Participants
Input
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane]
(Homo sapiens)
PTPN11 [cytosol]
(Homo sapiens)
Output
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:PTPN11 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Activated NTRK2 signals through FRS2 and FRS3 (Homo sapiens)
Inferred From
Ntrk2-phosphorylated Frs2 binds Ptpn11 (Homo sapiens)
Authored
Orlic-Milacic, M (2018-01-05)
Reviewed
Castrén, E (2018-02-13)
Antila, H (2018-02-13)
Created
Orlic-Milacic, M (2017-12-04)
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