EGR1, 2 and 3 have been shown to bind to cognate response elements in the ARC promoter and upregulate gene expression (Li et al, 2005; Mullenbrock et al, 2011, Adams et al, 2017). EGR1 and 2 protein and transcript levels are upregulated in response to sustained NGF signaling, while EGR3 transcript but not protein levels increase with NGF treatment (Adams et al, 2017). EGR3-dependent ARC expression may contribute to the delayed, protein-synthesis dependent increase in ARC protein levels (Li et al, 2005).
Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S
Whitehead, J, Gao, X, Li, L, Tourtellotte, WG, Carter, J
Cooper, GM, Mullenbrock, S, Shah, J
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