EGR binds ARC gene

Stable Identifier
R-HSA-9031616
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EGR binds ARC gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

EGR1, 2 and 3 have been shown to bind to cognate response elements in the ARC promoter and upregulate gene expression (Li et al, 2005; Mullenbrock et al, 2011, Adams et al, 2017). EGR1 and 2 protein and transcript levels are upregulated in response to sustained NGF signaling, while EGR3 transcript but not protein levels increase with NGF treatment (Adams et al, 2017). EGR3-dependent ARC expression may contribute to the delayed, protein-synthesis dependent increase in ARC protein levels (Li et al, 2005).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Egr1, Egr3 bind the Arc promoter (Mus musculus)
Egr1, Egr2 bind the Arc gene (Rattus norvegicus)
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2017-12-01)