EGR binds ARC gene

Stable Identifier
R-HSA-9031616
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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EGR binds ARC gene
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EGR1, 2 and 3 have been shown to bind to cognate response elements in the ARC promoter and upregulate gene expression (Li et al, 2005; Mullenbrock et al, 2011, Adams et al, 2017). EGR1 and 2 protein and transcript levels are upregulated in response to sustained NGF signaling, while EGR3 transcript but not protein levels increase with NGF treatment (Adams et al, 2017). EGR3-dependent ARC expression may contribute to the delayed, protein-synthesis dependent increase in ARC protein levels (Li et al, 2005).
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Inferred From
Egr1, Egr2 bind the Arc gene (Rattus norvegicus)
Egr1, Egr3 bind the Arc promoter (Mus musculus)
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2017-12-01)
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