Expression of APOC2 regulated by NR1H2 or NR1H3

Stable Identifier
R-HSA-9031527
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The APOC2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Ligand-activated liver X receptors (LXRα, NR1H3 and LXRβ NR1H2) induce expression of a cluster of apolipoprotein genes APOE, APOC1, APOC2 and APOC4 in both human and mouse macrophages (Mak PA et al. 2002). The induction of all four mRNAs was greatly attenuated in peritoneal macrophages derived from LXR α/β-/- mice (Mak PA et al. 2002). Cel reporter assays suggest that the LXR response elements (LXRE) in the multienhancer regions ME.1 and ME.2, which confer tissue-specific expression in macrophages and adipocytes (Shih SJ et al. 2000), are necessary for the expression of this gene cluster (Mak PA et al. 2002). These secreted apolipoproteins regulate lipid transport and catabolism.

Literature References
PubMed ID Title Journal Year
12032151 Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

Mak, PA, Laffitte, BA, Desrumaux, C, Joseph, SB, Curtiss, LK, Mangelsdorf, DJ, Tontonoz, P, Edwards, PA

J. Biol. Chem. 2002
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created
Cite Us!