Expression of APOC1 regulated by NR1H2 or NR1H3

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R-HSA-9031510
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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The APOC1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Ligand-activated liver X receptors (LXRα, NR1H3 and LXRβ NR1H2) induce expression of a cluster of apolipoprotein genes APOE, APOC1, APOC2 and APOC4 in both human and mouse macrophages (Mak PA et al. 2002). Induction of APOC2 mRNA was attenuated or abolished in macrophages derived from LXR α/β-/- mice (Mak PA et al. 2002).

Literature References
PubMed ID Title Journal Year
12032151 Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

Mak, PA, Laffitte, BA, Desrumaux, C, Joseph, SB, Curtiss, LK, Mangelsdorf, DJ, Tontonoz, P, Edwards, PA

J. Biol. Chem. 2002
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