Based on known mechanism of importin-alpha:importin-beta mode of action, cargo imported to the nucleus dissociates from the importin alpha/beta complex in a Ran:GTP-dependent manner. Dissociation of the DFF complex from the importin alpha/beta complex is therefore assumed. Ran:GTP is not shown as its role has not been studied in the context of the DFF complex (Neimanis et al. 2007).
Kahle, J, Neimanis, S, Doenecke, D, Albig, W
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