DFF dissociates from importin-alpha:importin-beta

Stable Identifier
R-HSA-9029667
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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DFF dissociates from importin-alpha:importin-beta
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Based on known mechanism of importin-alpha:importin-beta mode of action, cargo imported to the nucleus dissociates from the importin alpha/beta complex in a Ran:GTP-dependent manner. Dissociation of the DFF complex from the importin alpha/beta complex is therefore assumed. Ran:GTP is not shown as its role has not been studied in the context of the DFF complex (Neimanis et al. 2007).

Literature References
PubMed ID Title Journal Year
17938174 Sequence elements in both subunits of the DNA fragmentation factor are essential for its nuclear transport

Neimanis, S, Albig, W, Doenecke, D, Kahle, J

J Biol Chem 2007
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Authored
Matthews, L  (2008-01-29)
Reviewed
Widlak, P  (2008-05-08)
Created
Orlic-Milacic, M  (2017-11-21)