Reactome | EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1

Stable Identifier

R-HSA-9029150

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1

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Phosphorylated SHC1 in a complex with the activated EPOR binds GRB2 bound to VAV1 (Hanazono et al. 1995, Hanazono et al. 1996, Odai et al. 1997). GRB2 exists in pre-assembled complexes with VAV1 (Hanazono et al. 1995), SOS1 (Odai et al. 1997), or CBL (Odai et al. 1997). VAV1 and SOS1 are guanine nucleotide exchange factors that activate the RAS signaling pathway.

Literature References

PubMed ID	Title	Journal	Year
7539782	Tyrosine phosphorylation of the proto-oncogene product Vav and its association with the adapter Grb2/Ash in a human leukemia cell line UT-7 Yazaki, Y, Mitani, K, Hanazono, Y, Odai, H, Hirai, H, Sasaki, K, Mimura, T	Jpn. J. Cancer Res.	1995
8677749	Proto-oncogene products Vav and c-Cbl are involved in the signal transduction through Grb2/Ash in hematopoietic cells Yazaki, Y, Hanazono, Y, Odai, H, Hirai, H, Sasaki, K, Iwamatsu, A	Acta Haematol.	1996
9209406	The signal transduction through Grb2/Ash in hematopoietic cells Yazaki, Y, Hanazono, Y, Odai, H, Iwamatu, A, Hirai, H, Sasaki, K	Leukemia	1997