EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1

Stable Identifier
Reaction [binding]
Homo sapiens
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Phosphorylated SHC1 in a complex with the activated EPOR binds GRB2 bound to VAV1 (Hanazono et al. 1995, Hanazono et al. 1996, Odai et al. 1997). GRB2 exists in pre-assembled complexes with VAV1 (Hanazono et al. 1995), SOS1 (Odai et al. 1997), or CBL (Odai et al. 1997). VAV1 and SOS1 are guanine nucleotide exchange factors that activate the RAS signaling pathway.

Literature References
PubMed ID Title Journal Year
8677749 Proto-oncogene products Vav and c-Cbl are involved in the signal transduction through Grb2/Ash in hematopoietic cells

Hanazono, Y, Odai, H, Sasaki, K, Iwamatsu, A, Yazaki, Y, Hirai, H

Acta Haematol. 1996
7539782 Tyrosine phosphorylation of the proto-oncogene product Vav and its association with the adapter Grb2/Ash in a human leukemia cell line UT-7

Hanazono, Y, Sasaki, K, Odai, H, Mimura, T, Mitani, K, Yazaki, Y, Hirai, H

Jpn. J. Cancer Res. 1995
9209406 The signal transduction through Grb2/Ash in hematopoietic cells

Odai, H, Hanazono, Y, Sasaki, K, Iwamatu, A, Yazaki, Y, Hirai, H

Leukemia 1997
Orthologous Events
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