Activation of NTRK2 (TrkB) by binding to BDNF or NTF4 (NT-4) leads to phosphorylation of FRS2 (also known as SNT or FRS2alpha) (Yuen and Mobley 1999). FRS2 binds to phosphorylated tyrosine Y516 of activated NTRK2 (Zeng et al. 2014 - Y516 is mislabeled as Y512 in the paper). Human FRS2 was also shown to bind to intracellular domain of rat Ntrk2 (Dixon et al. 2006).
Zhou, MM, Mujtaba, S, Zeng, L, Kuti, M
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