Activated NTRK2 binds FRS2

Stable Identifier
R-HSA-9028730
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Activated NTRK2 binds FRS2
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Activation of NTRK2 (TrkB) by binding to BDNF or NTF4 (NT-4) leads to phosphorylation of FRS2 (also known as SNT or FRS2alpha) (Yuen and Mobley 1999). FRS2 binds to phosphorylated tyrosine Y516 of activated NTRK2 (Zeng et al. 2014 - Y516 is mislabeled as Y512 in the paper). Human FRS2 was also shown to bind to intracellular domain of rat Ntrk2 (Dixon et al. 2006).
Literature References
PubMed ID Title Journal Year
24470253 Structural insights into FRS2α PTB domain recognition by neurotrophin receptor TrkB

Zhou, MM, Mujtaba, S, Zeng, L, Kuti, M

Proteins 2014
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Orthologous Events
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Activated NTRK2 binds FRS2 (Mus musculus)
Activated NTRK2 binds FRS2 (Rattus norvegicus)
Activated NTRK2 binds FRS2 (Sus scrofa)
Activated NTRK2 binds FRS2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-09)
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