PGH3 spontaneously dehydrates to PGJ3

Stable Identifier
R-HSA-9028273
Type
Reaction [transition]
Species
Homo sapiens
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It is proposed that EPA-derived prostaglandin H3 (PGH3) undergoes nonenzymatic dehydration to form prostaglandin J3 (PGJ3) (Fitzpatrick et al. 1983, Shibata et al. 2002). EPA supplementation to mice resulted in enhanced endogenous production of 15-deoxy-PGJ3 (15d-PGJ3), the final deoxy-product of EPA (Lefils-Lacourtablaise et al. 2013).

Literature References
PubMed ID Title Journal Year
6578214 Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro

Fitzpatrick, FA, Wynalda, MA

J. Biol. Chem. 1983
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