PGJ3 isomerises to δ12-PGJ3

Stable Identifier
R-HSA-9028263
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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It is proposed that prostaglandin J3 (PGJ3) isomerises to prostaglandin δ12-PGJ3 (δ12-PGJ3) (Fitzpatrick et al. 1983, Shibata et al. 2002). EPA supplementation to mice resulted in enhanced endogenous production of δ12-PGJ3, which was found to possess chemoprotective activity against myleoid leukemia, ablating leukemia stem cells in mice (Hedge et al. 2011, Finch et al. 2015).

Literature References
PubMed ID Title Journal Year
6578214 Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro

Fitzpatrick, FA, Wynalda, MA

J. Biol. Chem. 1983
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