δ12-PGJ3 spontaneously dehydrates to 15d-PGJ3

Stable Identifier
R-HSA-9028260
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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It is proposed that δ12-prostaglandin-J3 ( δ12-PGJ3) undergoes a second dehydration to form 15-deoxy-prostaglandin J3 (15d-PGJ3) (Fitzpatrick et al. 1983, Shibata et al. 2002). Oxo-fatty acids, like 15d-PGJ3, can covalently bind and activate the peroxisome proliferator-activated receptor γ (PPARγ) and inhibit pro-inflammatory cytokine and nitric oxide production (Groeger et al. 2010, Waku et al. 2009, Shibata et al. 2002, Lefils-Lacourtablaise et al. 2013). In mice, oxo-prostaglandins such as 15d-PGJ3 may have a chemopreventative effect in myeloid leukemia (Finch et al. 2015, Hedge et al. 2011).

Literature References
PubMed ID Title Journal Year
6578214 Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro

Fitzpatrick, FA, Wynalda, MA

J. Biol. Chem. 1983
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