5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA

Stable Identifier
R-HSA-9027632
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In neutrophils, 5-hydroxyeicosanoid dehydrogenase (5-HEDH) activity is localised in the microsomal fraction and requires NADP+ as a cofactor to oxidise 5-hydroxy-eicosapentaenoic acid (5-HEPE) to 5-oxo-eicosapentaenoic acid (5-oxo-EPA) (Powell et al. 1995, Patel et al. 2009). Although 5-HEDH activity has been found in a wide range of intact cells and in crude microsome preparations, the enzyme has not yet been purified, its structure is unknown, and the gene that encodes it remains to be identified. Dietary EPA supplementation significantly increases the formation of 5-oxo-EPA that transduces anti-inflammatory actions rather than suppressing production of pro-inflammatory AA metabolites (Cipollina et al. 2014).

Literature References
PubMed ID Title Journal Year
8847485 Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils

Powell, WS, Gravel, S, Gravelle, F

J. Lipid Res. 1995
24736647 Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives

Cipollina, C, Salvatore, SR, Muldoon, MF, Freeman, BA, Schopfer, FJ

PLoS ONE 2014
19164464 Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids

Patel, P, Cossette, C, Anumolu, JR, Erlemann, KR, Grant, GE, Rokach, J, Powell, WS

J. Pharmacol. Exp. Ther. 2009
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Catalyst Activity
Title
NADPH dehydrogenase activity of 5-HEDH [endoplasmic reticulum membrane]
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