5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA

Stable Identifier
R-HSA-9027631
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In neutrophils, 5 hydroxyeicosanoid dehydrogenase (5-HEDH) activity is localised in the microsomal fraction and requires NADP+ as a cofactor to oxidise 7-hydroxy docosahexaenoic acid (7-HDHA) to 7-oxo-docosahexaenoic acid (7-oxo-DHA) (Patel et al. 2009, Cipollina et al. 2014). Although 5-HEDH activity has been evaluated in a wide range of intact cells and in crude microsome preparations, it has not yet been purified and its structure and gene remain unknown. Dietary EPA supplementation significantly increases the formation of 7-oxo-DHA that transduces anti inflammatory actions rather than suppressing production of pro inflammatory AA metabolites (Cipollina et al. 2014).

Literature References
PubMed ID Title Journal Year
19164464 Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids

Patel, P, Cossette, C, Anumolu, JR, Erlemann, KR, Grant, GE, Rokach, J, Powell, WS

J. Pharmacol. Exp. Ther. 2009
24736647 Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives

Cipollina, C, Salvatore, SR, Muldoon, MF, Freeman, BA, Schopfer, FJ

PLoS ONE 2014
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Catalyst Activity

NADPH dehydrogenase activity of 5-HEDH [endoplasmic reticulum membrane]

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