5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3

Stable Identifier
R-HSA-9027625
Type
Reaction [transition]
Species
Homo sapiens
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In neutrophils, 5-hydroxyeicosanoid dehydrogenase (5-HEDH) activity is localised in the microsomal fraction and requires NADP+ as a cofactor to oxidise 7-hydroxy-ω-3-docosapentaenoic acid (7-HDPAn-3) to 7-oxo-ω-3-docosapentaenoic acid (7-oxo-DPAn-3) (Patel et al. 2009, Cipollina et al. 2014). Although 5-HEDH activity has been found in a wide range of intact cells and in crude microsome preparations, the enzyme has not yet been purified, its structure is unknown, and the gene that encodes it remains to be identified. Dietary EPA supplementation significantly increases the formation of 7-oxo-DPAn-3 that transduces anti-inflammatory actions rather than suppressing production of pro-inflammatory AA metabolites (Cipollina et al. 2014).

Literature References
PubMed ID Title Journal Year
19164464 Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids

Patel, P, Cossette, C, Anumolu, JR, Erlemann, KR, Grant, GE, Rokach, J, Powell, WS

J. Pharmacol. Exp. Ther. 2009
24736647 Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives

Cipollina, C, Salvatore, SR, Muldoon, MF, Freeman, BA, Schopfer, FJ

PLoS ONE 2014
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Title
NADPH dehydrogenase activity of 5-HEDH [endoplasmic reticulum membrane]
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