Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA

Stable Identifier
R-HSA-9027531
Type
Reaction [transition]
Species
Homo sapiens
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In activated macrophages, an unknown dehdyrogenase abstracts hydrogen from 13-hydroxy-docosahexaenoic acid to form the electrophilic oxo-derivative (EFOX) 13-oxo-DHA (Groeger et al. 2010). Potential candidates are cellular dehydrogenases such as 3α-hydroxysteroid dehydrogenases (3α-HSDs), which can convert 13- and 17-HDHA into their corresponding oxo-derivatives in the presence of NAD(P)+ in vitro (supplementary data, Groeger et al. 2010) or 5- and 15-hydroxyeicosanoid dehydrogenases (5- and 15-HEDH), which convert LOX products to 5-and 15-oxoETE (Erlemann et al. 2007). EFOXs can act as peroxisome proliferator-activated receptor-γ (PPARγ) agonists and inhibit pro-inflammatory cytokine and nitric oxide production, confirming their anti-inflammatory actions (Groeger et al. 2010).

Literature References
PubMed ID Title Journal Year
20436486 Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids

Groeger, AL, Cipollina, C, Cole, MP, Woodcock, SR, Bonacci, G, Rudolph, TK, Rudolph, V, Freeman, BA, Schopfer, FJ

Nat. Chem. Biol. 2010
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Catalyst Activity
Title
aldo-keto reductase (NADP) activity of Dehydrogenase [cytosol]
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