Erythropoietin activates STAT5

Stable Identifier
R-HSA-9027283
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Erythropoietin activates STAT5
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STAT5 (STAT5A or STAT5B) directly binds the phosphorylated cytoplasmic domain of EPOR, where it is phosphorylated by JAK2 and LYN (Oda et al. 1998, inferred from mouse homologs, reviewed in Kuhrt and Wojchowski 2015). Phosphorylated STAT5 then dissociates from EPOR, dimerizes, and transits to the nucleus where it activates gene expression.

Literature References
PubMed ID Title Journal Year
25887776 Emerging EPO and EPO receptor regulators and signal transducers

Wojchowski, DM, Kuhrt, D

Blood 2015
9657743 Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors

Oda, A, Koike, T, Druker, BJ, Sawada, K, Ozaki, K, Koizumi, K, Ikeda, Y, Handa, M, Fukada, Y, Takano, H

Blood 1998
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Go Biological Process
positive regulation of receptor signaling pathway via STAT (1904894)
Cross References
BioModels Database
Authored
May, B  (2017-10-29)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-10-29)
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