Reactome | EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1

Stable Identifier

R-HSA-9027281

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1

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GAB1 binds directly to phosphotyrosines 344 and 402 of the EPOR (Bouscary et al. 2003, Montoye et al. 2005). GAB1 can also indirectly bind the EPOR via SHC1 or GRB2. GAB2 is absent from human erythroid progenitors but present in mouse erythroid progenitors (Wickrema et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10455108	Engagement of Gab1 and Gab2 in erythropoietin signaling Krystal, G, Ahmad, S, Chen, F, Sharma, A, Sawyer, ST, Platanias, LC, Nishada, K, Hirano, T, Hibi, M, Yi, T, Alsayed, Y, Uddin, S, Wickrema, A	J Biol Chem	1999
12506011	Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation Claessens, YE, Mayeux, P, Fontenay-Roupie, M, Bouscary, D, Pene, F, Lacombe, C, Muller, O, Chrétien, S, Gisselbrecht, S	Blood	2003
15644415	A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach Lemmens, I, Eyckerman, S, Catteeuw, D, Tavernier, J, Montoye, T	Blood	2005