EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1

Stable Identifier
R-HSA-9027281
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GAB1 binds directly to phosphotyrosines 344 and 402 of the EPOR (Bouscary et al. 2003, Montoye et al. 2005). GAB1 can also indirectly bind the EPOR via SHC1 or GRB2. GAB2 is absent from human erythroid progenitors but present in mouse erythroid progenitors (Wickrema et al. 1999).

Literature References
PubMed ID Title Journal Year
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Bouscary, D, Pene, F, Claessens, YE, Muller, O, Chr├ętien, S, Fontenay-Roupie, M, Gisselbrecht, S, Mayeux, P, Lacombe, C

Blood 2003
10455108 Engagement of Gab1 and Gab2 in erythropoietin signaling

Wickrema, A, Uddin, S, Sharma, A, Chen, F, Alsayed, Y, Ahmad, S, Sawyer, ST, Krystal, G, Yi, T, Nishada, K, Hibi, M, Hirano, T, Platanias, LC

J Biol Chem 1999
15644415 A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach

Montoye, T, Lemmens, I, Catteeuw, D, Eyckerman, S, Tavernier, J

Blood 2005
Participants
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