Reactome | EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K

Stable Identifier

R-HSA-9027275

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K

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Phosphorylated GAB1 in a complex with EPOR binds the p85 subunit of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) (Lecoq-Lafon et al. 1999, Wickrema et al. 1999, Bouscary et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
10194437	Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and phosphatidylinositol 3-kinase Lecoq-Lafon, C, Verdier, F, Fichelson, S, Chrétien, S, Gisselbrecht, S, Lacombe, C, Mayeux, P	Blood	1999
10455108	Engagement of Gab1 and Gab2 in erythropoietin signaling Wickrema, A, Uddin, S, Sharma, A, Chen, F, Alsayed, Y, Ahmad, S, Sawyer, ST, Krystal, G, Yi, T, Nishada, K, Hibi, M, Hirano, T, Platanias, LC	J Biol Chem	1999
12506011	Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation Bouscary, D, Pene, F, Claessens, YE, Muller, O, Chrétien, S, Fontenay-Roupie, M, Gisselbrecht, S, Mayeux, P, Lacombe, C	Blood	2003