EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K

Stable Identifier
Reaction [binding]
Homo sapiens
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Phosphorylated GAB1 in a complex with EPOR binds the p85 subunit of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) (Lecoq-Lafon et al. 1999, Wickrema et al. 1999, Bouscary et al. 2003).

Literature References
PubMed ID Title Journal Year
10194437 Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and phosphatidylinositol 3-kinase

Mayeux, P, Lecoq-Lafon, C, Lacombe, C, Verdier, F, Gisselbrecht, S, Chr├ętien, S, Fichelson, S

Blood 1999
10455108 Engagement of Gab1 and Gab2 in erythropoietin signaling

Krystal, G, Ahmad, S, Chen, F, Sharma, A, Sawyer, ST, Platanias, LC, Nishada, K, Hirano, T, Hibi, M, Yi, T, Alsayed, Y, Uddin, S, Wickrema, A

J Biol Chem 1999
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Claessens, YE, Mayeux, P, Fontenay-Roupie, M, Bouscary, D, Pene, F, Lacombe, C, Muller, O, Chr├ętien, S, Gisselbrecht, S

Blood 2003
Orthologous Events
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