IRS2 is constitutively associated with EPOR and is phosphorylated on tyrosine residues in response to EPO (Verdier et al. 1997, Bouscary et al. 2003). The phosphorylated IRS2 serves as a docking site for downstream signaling proteins, notably phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) (Bouscary et al. 2003).
Bouscary, D, Pene, F, Claessens, YE, Muller, O, Chrétien, S, Fontenay-Roupie, M, Gisselbrecht, S, Mayeux, P, Lacombe, C
Verdier, F, Chrétien, S, Billat, C, Gisselbrecht, S, Lacombe, C, Mayeux, P
protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
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