EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2

Stable Identifier
R-HSA-9027272
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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IRS2 is constitutively associated with EPOR and is phosphorylated on tyrosine residues in response to EPO (Verdier et al. 1997, Bouscary et al. 2003). The phosphorylated IRS2 serves as a docking site for downstream signaling proteins, notably phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) (Bouscary et al. 2003).

Literature References
PubMed ID Title Journal Year
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Bouscary, D, Pene, F, Claessens, YE, Muller, O, Chr├ętien, S, Fontenay-Roupie, M, Gisselbrecht, S, Mayeux, P, Lacombe, C

Blood 2003
9334184 Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation

Verdier, F, Chr├ętien, S, Billat, C, Gisselbrecht, S, Lacombe, C, Mayeux, P

J. Biol. Chem. 1997
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]

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