Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA

Stable Identifier
R-HSA-9027033
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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An unidentified hydroperoxy reductase reduces 14(S)-hydroperoxy-docosahexaenoic acid (14(S)-Hp-DHA) to form 14(S)-hydroxy-docosahexaenoic acid (14(S)-HDHA), the precursor for the formation of maresin-like mediator Mar-L1 (Hong et al. 2014) and 14(S),21-dihydroxy-docosahexaenoic acids (Lu et al. 2010).

Literature References
PubMed ID Title Journal Year
25200603 Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages

Hong, S, Lu, Y, Tian, H, Alapure, BV, Wang, Q, Bunnell, BA, Laborde, JM

Chem. Biol. 2014
Participants
Participates
Catalyst Activity

oxidoreductase activity of Hydroperoxy reductase [cytosol]

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