Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA

Stable Identifier
R-HSA-9027033
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA
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An unidentified hydroperoxy reductase reduces 14(S)-hydroperoxy-docosahexaenoic acid (14(S)-Hp-DHA) to form 14(S)-hydroxy-docosahexaenoic acid (14(S)-HDHA), the precursor for the formation of maresin-like mediator Mar-L1 (Hong et al. 2014) and 14(S),21-dihydroxy-docosahexaenoic acids (Lu et al. 2010).
Literature References
PubMed ID Title Journal Year
25200603 Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages

Alapure, BV, Lu, Y, Tian, H, Bunnell, BA, Wang, Q, Hong, S, Laborde, JM

Chem. Biol. 2014
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Catalyst Activity

oxidoreductase activity of Hydroperoxy reductase [cytosol]

Physical Entity
Hydroperoxy reductase [cytosol] (Homo sapiens)
Activity
oxidoreductase activity (GO:0016491)
Authored
Jassal, B  (2017-10-27)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-27)
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