Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA

Stable Identifier
R-HSA-9027033
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA
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An unidentified hydroperoxy reductase reduces 14(S)-hydroperoxy-docosahexaenoic acid (14(S)-Hp-DHA) to form 14(S)-hydroxy-docosahexaenoic acid (14(S)-HDHA), the precursor for the formation of maresin-like mediator Mar-L1 (Hong et al. 2014) and 14(S),21-dihydroxy-docosahexaenoic acids (Lu et al. 2010).

Literature References
PubMed ID Title Journal Year
25200603 Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages

Hong, S, Lu, Y, Tian, H, Alapure, BV, Wang, Q, Bunnell, BA, Laborde, JM

Chem. Biol. 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity of Hydroperoxy reductase [cytosol]
Physical Entity
Hydroperoxy reductase [cytosol]
Activity
oxidoreductase activity (0016491)
Authored
Jassal, B  (2017-10-27)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-27)
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