Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA

Stable Identifier
R-HSA-9026918
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA
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In an alternative route to PCTR production, 17(S)-hydroperoxy-docosahexaenoic acid (17(S)-Hp-DHA) can undergo a second lipoxygenation at carbon 7 position to yield 7S,17S-dihydroperoxy-docosahexaenoic acid (7(S),17(S)-diHp-DHA). A lipoxygenase mediates this reaction although the exact human enzyme is unknown (Dalli et al. 2015).
Literature References
PubMed ID Title Journal Year
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Norris, PC, Serhan, CN, Colas, RA, Ramon, S, Dalli, J

FASEB J. 2015
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Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of Lipoxygenase [cytosol]

Physical Entity
Lipoxygenase [cytosol] (Homo sapiens)
Activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)
Authored
Jassal, B  (2017-10-24)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-24)
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