Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA

Stable Identifier
R-HSA-9026918
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In an alternative route to PCTR production, 17(S)-hydroperoxy-docosahexaenoic acid (17(S)-Hp-DHA) can undergo a second lipoxygenation at carbon 7 position to yield 7S,17S-dihydroperoxy-docosahexaenoic acid (7(S),17(S)-diHp-DHA). A lipoxygenase mediates this reaction although the exact human enzyme is unknown (Dalli et al. 2015).

Literature References
PubMed ID Title Journal Year
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Dalli, J, Ramon, S, Norris, PC, Colas, RA, Serhan, CN

FASEB J. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of Lipoxygenase [cytosol]
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