Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA

Stable Identifier
R-HSA-9026917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA
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A lipoxygenase may mediate hydrogen abstraction from 7(S),17(S)-dihydroperoxy-docosahexaenoic acid (7(S),17(S)-diHp-DHA) to form 7S(8)-epoxy-17(S)-hydroxy-docosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) (Dalli et al. 2015). This epoxy intermediate is the precursor for resolvin conjugates in tissue regeneration (RCTR).
Literature References
PubMed ID Title Journal Year
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Norris, PC, Serhan, CN, Colas, RA, Ramon, S, Dalli, J

FASEB J. 2015
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Catalyst Activity

oxidoreductase activity of Lipoxygenase [cytosol]

Physical Entity
Lipoxygenase [cytosol] (Homo sapiens)
Activity
oxidoreductase activity (GO:0016491)
Authored
Jassal, B  (2017-10-24)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-24)
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