Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA

Stable Identifier
R-HSA-9026917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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A lipoxygenase may mediate hydrogen abstraction from 7(S),17(S)-dihydroperoxy-docosahexaenoic acid (7(S),17(S)-diHp-DHA) to form 7S(8)-epoxy-17(S)-hydroxy-docosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) (Dalli et al. 2015). This epoxy intermediate is the precursor for resolvin conjugates in tissue regeneration (RCTR).

Literature References
PubMed ID Title Journal Year
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Dalli, J, Ramon, S, Norris, PC, Colas, RA, Serhan, CN

FASEB J. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity of Lipoxygenase [cytosol]
Physical Entity
Activity
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