Reactome | LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1

LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1

Stable Identifier

R-HSA-9026911

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
    - Biosynthesis of DHA-derived SPMs (Homo sapiens)
      - Biosynthesis of DHA-derived sulfido conjugates (Homo sapiens)
        
        Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) (Homo sapiens)
        
        LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Homo sapiens)

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LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1

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Just as the addition of glutathione (GSH) to an allylic epoxide is governed by glutathione S-transferase enzymes in the biosynthesis of MCTR (Dalli et al. 2016), 7S(8)-epoxy-17(S)-hydroxy-docosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) may presumably be conjugated with GSH by trimeric leukotriene C4 synthase (LTC4S trimer) to form resolvin conjugate in tissue regeneration 1 (RCTR1, 8-glutathionyl, 7,17-dihydroxy-docosahexaenoic acid) (Dalli et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25713027	Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways Norris, PC, Serhan, CN, Colas, RA, Ramon, S, Dalli, J	FASEB J.	2015